Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review.

Advances in Wound Care
Olivia A CharltonAlan Cooper

Abstract

Significance: Toxic epidermal necrolysis (TEN) and Steven-Johnson syndrome (SJS) are potentially fatal acute mucocutaneous vesiculobullous disorders. Evidence to date suggests that outcomes for patients with both TEN and SJS are largely dependent on stopping the causative agent, followed by supportive care and appropriate wound management in a specialized burns unit. These are life-threatening conditions characterized by widespread full-thickness cutaneous and mucosal necrosis. This article outlines the approach to holistic management of such patients, in a specialized unit, highlighting various practical aspects of wound care to prevent complications such as infection, mucosal and adhesions, and ocular scaring. Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed. Critical Issues: Following cessation of the culprit trigger, management in a specialized burns unit is the most important management step. It is now...Continue Reading

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Citations

May 25, 2021·Clinical Case Reports·Saeedeh Farajzadeh, Najmeh Ahramiyanpour
Aug 10, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Pranav N HaravuSebastian Q Vrouwe

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Methods Mentioned

BETA
sedation
xenograft
biopsies

Software Mentioned

RegiSCAR
COMET
EuroSCAR
SCORTEN

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