Toxic epidermal necrolysis associated with sorafenib and tosufloxacin in a patient with hepatocellular carcinoma.

Annals of Dermatology
Mun Ki ChoiMoon Bum Kim

Abstract

This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discontinued, and the TEN resolved with corticosteroids and supportive treatment. Clinical physicians should be aware of this possible complication so that early interventions can be made.

References

Jan 1, 1979·The British Journal of Dermatology·A Lyell
Nov 1, 1992·International Journal of Dermatology·J M Parsons
Dec 1, 1990·Journal of the American Academy of Dermatology·J C RoujeauJ C Guillaume
Sep 1, 1987·Archives of Dermatology·J C GuillaumeR Touraine
Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Jun 1, 1996·Burns : Journal of the International Society for Burn Injuries·A K Khoo, C L Foo
May 21, 1998·Lancet·D S Becker
Aug 22, 2000·The Journal of Investigative Dermatology·S Bastuji-GarinP Wolkenstein
Nov 28, 2001·Clinical and Experimental Dermatology·J B van der MeerP Nieuwenhuis
Mar 29, 2002·The Journal of Investigative Dermatology·Amal NassifJean-Claude Roujeau
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Lars E French
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group

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Citations

Jun 12, 2013·European Journal of Clinical Pharmacology·Emmanuelle FayeUNKNOWN French Network of Regional Pharmacovigilance Centers

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Methods Mentioned

BETA
biopsy

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