Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Pediatric Transplantation
Utako ObaKenji Ihara

Abstract

TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

References

Apr 23, 2003·The American Journal of Pathology·Riichiro AbeHiroshi Shimizu
Nov 16, 2011·Internal Medicine·Tetsukan WooYoshiaki Ishigatsubo
Dec 16, 2011·Journal of the American Academy of Dermatology·Andrew DowneyAlan Cooper
Jan 4, 2013·Stem Cells Translational Medicine·Anthony D Sung, Nelson J Chao
Jul 19, 2013·ISRN Dermatology·G E PiérardC Piérard-Franchimont
Jul 23, 2013·Archives of Disease in Childhood·Carla Ferrandiz-Pulido, Vicente Garcia-Patos

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Citations

Jun 8, 2018·Current Opinion in Pediatrics·Trisha Bhat, Carrie C Coughlin
Nov 27, 2018·Pediatric Dermatology·Amanda Leal RochaTarcília Aparecida da Silva
Jun 22, 2021·Cutaneous and Ocular Toxicology·Miloš N MilosavljevićJovana Z Milosavljević

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