Dec 1, 2008

Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide

Annals of Dermatology
Ji Sun ChunSeung Chul Lee

Abstract

Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic CAIs are the most potent medications for lowering intraocular pressure for conditions with ocular hypertension, many cases with adverse systemic reactions have been reported, including Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN). Here, we report 2 cases of TEN that were associated with topical CAIs rather than systemic CAIs.

Mentioned in this Paper

Ocular Hypertension
Adverse Effects
Pharmaceutical Preparations
Stevens-Johnson Syndrome
Toxic Epidermal Necrolysis
Schwartz-Jampel Syndrome
Dorzolamide
Calcium-Independent Phospholipase A2
Physiologic Intraocular Pressure
Carbonic Anhydrase Inhibitors

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