Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia

Veterinary Pathology
H T ChangA P Knight


Chronic ingestion of yellow star thistle (Centaurea solstitialis) or Russian knapweed (Acroptilon repens) causes nigropallidal encephalomalacia (NPE) in horses with an abrupt onset of neurologic signs characterized by dystonia of lips and tongue, inability to prehend food, depression, and locomotor deficits. The objectives of this study were to reexamine the pathologic alterations of NPE and to conduct an immunohistochemistry study using antibodies to tyrosine hydroxylase and α-synuclein, to determine whether NPE brains show histopathologic features resembling those in human Parkinson disease. Results confirm that the NPE lesions are located within the substantia nigra pars reticulata, sparing the cell bodies of the dopaminergic neurons in the substantia nigra pars compacta, and in the rostral portion of the globus pallidus, with partial disruption of dopaminergic (tyrosine hydroxylase-positive) fibers passing through the globus pallidus. No abnormal cytoplasmic inclusions like the Lewy bodies of human Parkinson disease were seen in these NPE brains. These findings indicate that equine NPE may serve as a large animal model of environmentally acquired toxic parkinsonism, with clinical phenotype directly attributable to lesions i...Continue Reading


Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K InamuraB K Siesjö
Feb 1, 1973·Australian Veterinary Journal·G P GardP J Ahrens
Jul 31, 1998·Experimental Neurology·M RoblesR C Kim
Jun 29, 2000·Neurologic Clinics·R L Albin
Aug 14, 2001·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·S G SandersP R Gavin
Jun 20, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Michael Orth, Sarah J Tabrizi
Apr 1, 1954·Journal of Neuropathology and Experimental Neurology·D R CORDY
Sep 24, 2004·The American Journal of Medicine·Chadwick W Christine, Michael J Aminoff
Nov 5, 2008·Journal of Medical Genetics·A GregoryS J Hayflick
Nov 17, 2009·Lancet Neurology·Dennis W DicksonIrene Litvan

❮ Previous
Next ❯


Jun 4, 2015·The Veterinary Clinics of North America. Equine Practice·Ahmad Al-Dissi
Aug 28, 2020·Frontiers in Veterinary Science·Samuel BoucherGiovanni Mogicato
Feb 19, 2020·Journal of Equine Veterinary Science·Abubakar Musa MayakiAbdullah Rasedee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
S G SandersP R Gavin
Journal of Neuropathology and Experimental Neurology
Daniel P Perl, C Warren Olanow
Current Drug Targets. CNS and Neurological Disorders
S M CardosoC R Oliveira
© 2021 Meta ULC. All rights reserved