Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia

Veterinary Pathology
H T ChangA P Knight

Abstract

Chronic ingestion of yellow star thistle (Centaurea solstitialis) or Russian knapweed (Acroptilon repens) causes nigropallidal encephalomalacia (NPE) in horses with an abrupt onset of neurologic signs characterized by dystonia of lips and tongue, inability to prehend food, depression, and locomotor deficits. The objectives of this study were to reexamine the pathologic alterations of NPE and to conduct an immunohistochemistry study using antibodies to tyrosine hydroxylase and α-synuclein, to determine whether NPE brains show histopathologic features resembling those in human Parkinson disease. Results confirm that the NPE lesions are located within the substantia nigra pars reticulata, sparing the cell bodies of the dopaminergic neurons in the substantia nigra pars compacta, and in the rostral portion of the globus pallidus, with partial disruption of dopaminergic (tyrosine hydroxylase-positive) fibers passing through the globus pallidus. No abnormal cytoplasmic inclusions like the Lewy bodies of human Parkinson disease were seen in these NPE brains. These findings indicate that equine NPE may serve as a large animal model of environmentally acquired toxic parkinsonism, with clinical phenotype directly attributable to lesions i...Continue Reading

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Citations

Jun 4, 2015·The Veterinary Clinics of North America. Equine Practice·Ahmad Al-Dissi
Aug 28, 2020·Frontiers in Veterinary Science·Samuel BoucherGiovanni Mogicato
Feb 19, 2020·Journal of Equine Veterinary Science·Abubakar Musa MayakiAbdullah Rasedee

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