PMID: 7544178Apr 1, 1995Paper

Toxic hematoma: an unusual and previously undescribed type of thyrotoxicosis

Thyroid : Official Journal of the American Thyroid Association
W R Skowsky

Abstract

The present case describes a new and unusual variant of thyrotoxicosis: transient hyperthyroxinemia following acute and massive hemorrhage into a previously normal thyroid gland. A 74-year-old woman presented with a large painful neck mass, palpitations, rapid atrial fibrillation, and hyperthyroxinemia following a fall and neck trauma while treated with excessive oral anticoagulants. Ultrasound and computerized tomography of the neck were consistent with a massive intrathyroidal hematoma. Elevation in serum T4 and T3 levels with suppressed TSH normalized over 3-4 weeks in parallel with hematoma shrinkage. Her tests were consistent with extensive bleeding into thyroidal tissue producing release of stored hormone. Her clinical course was compatible with the known disappearance rate of thyroxine and she returned to her euthyroid status without antithyroid therapy.

References

Mar 1, 1978·Clinics in Endocrinology and Metabolism·D S CooperF Maloof
May 1, 1973·Medicine·C R Hamilton, F Maloof

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Citations

May 21, 2011·Updates in Surgery·Gianluca Donatini
Aug 17, 2006·Thyroid : Official Journal of the American Thyroid Association·Tasoula TsilchorozidouNicolaos Grigoriadis
Dec 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Kanji Kasagi, Hiroaki Hattori
Dec 13, 2007·The Journal of Trauma·Akiyoshi HagiwaraShuji Shimazaki
Dec 30, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Laxmi KokatnurPenchala Mittadodla
May 15, 2007·The Journal of Emergency Medicine·Yoshio OkaMasaaki Izukura
Jun 15, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ibrahim Koral OnalNezaket Adalar
Jun 19, 2018·The Annals of Otology, Rhinology, and Laryngology·Rajini K Yatavelli, Steven N Levine
Jun 13, 2021·The American Journal of Emergency Medicine·Nelson H Bansil

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