PMID: 8611151Feb 1, 1996Paper

Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus

The Biochemical Journal
Baltazar BecerrilLourival D Possani

Abstract

Seven toxic peptides from the venom of Tityus bahiensis and Tityus stigmurus was isolated and sequenced, five of them to completion. The most abundant peptide from each of these two species of scorpion was 95% identical with that of toxin gamma from the venom of Tityus serrulatus. They were consequently named gamma-b and gamma-st respectively. The genes encoding these new gamma-like peptides were cloned and sequenced by utilizing oligonucleotides synthesized according to known cDNA sequences of toxin gamma, and amplified by PCR on templates of DNA purified from both T. bahiensis and T. stigmurus. They contain an intron of approx. 470 bp. Possible mechanisms of processing and expressing these peptides are discussed, in view of the fact that glycine is the first residue of the N-terminal sequence of T. stigmurus, whereas lysine is the residue at position 1 of toxin gamma from T. serrulatus and T. bahiensis. In addition, chemical characterization of the less abundant toxic peptides showed the presence of at least four distinct families of peptides in all three species of the genus Tityus studied. There is a large degree of similarity among peptides from different venoms of the same family. By using specific horse and rabbit antise...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1991·Current Opinion in Neurobiology·W A Catterall
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·M GurevitzN Zilberberg
Jan 1, 1986·Annals of the New York Academy of Sciences·H MevesD D Watt
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·B M MartinL D Possani
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J C Fontecilla-CampsC E Bugg
Aug 16, 1984·Biochemical and Biophysical Research Communications·G BechisH Rochat
Sep 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·L Freire-MaiaC F Amaral
Aug 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·A K NishikawaW D Da Silva
Mar 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·E S Calderon-ArandaL D Possani

❮ Previous
Next ❯

Citations

Jun 14, 2005·Journal of Molecular Graphics & Modelling·Paul T J TanVladimir Brusic
Apr 28, 2004·Toxicon : Official Journal of the International Society on Toxinology·Anna Rosa MurgiaLourival D Possani
Nov 10, 2000·Toxicon : Official Journal of the International Society on Toxinology·E KalapothakisC Chávez-Olórtegui
Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Geane Antiques LourençoValquiria A Coronado Dorce
Feb 1, 2002·Toxicon : Official Journal of the International Society on Toxinology·Cesar V F BatistaLourival D Possani
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Fredy V CoronasLourival D Possani
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Simone WagnerCarlos Alberto Schwartz
Nov 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·P L FletcherD M Terrian
Jun 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·B BecerrilL D Possani
Mar 18, 1999·Toxicon : Official Journal of the International Society on Toxinology·S C GuatimosimE Kalapothakis
May 26, 1999·Toxicon : Official Journal of the International Society on Toxinology·A BorgesP H Backx
Apr 29, 1999·Toxicon : Official Journal of the International Society on Toxinology·E S Calderón-ArandaC Bon
Apr 12, 2000·Toxicon : Official Journal of the International Society on Toxinology·C L PenaforteE Kalapothakis
Feb 24, 2015·Toxicon : Official Journal of the International Society on Toxinology·A O CarmoE Kalapothakis
Feb 3, 2005·Toxicon : Official Journal of the International Society on Toxinology·Elia Diego-GarcíaLourival D Possani
Mar 23, 2006·Toxicon : Official Journal of the International Society on Toxinology·Danielle G NascimentoAdriano M C Pimenta
Apr 20, 2005·Vaccine·Karlen G GazarianLourival D Possani
Mar 17, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·G D'SuzeA Alagón
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Sep 1, 2000·Revista Da Sociedade Brasileira De Medicina Tropical·R M Lira-da-SilvaT K Brazil
Apr 7, 2004·The Journal of Biological Chemistry·Xinsheng ZhuHéctor H Valdivia
Jun 6, 2003·European Journal of Biochemistry·Dalia GordonMichael Gurevitz
Feb 8, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leonor Abrahão NencioniValquiria Abrão Coronado Dorce
Oct 17, 2003·The Journal of Biological Chemistry·Isabelle HuysJan Tytgat
Sep 22, 1999·European Journal of Biochemistry·L D PossaniJ Tytgat
Dec 17, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Adolfo BorgesHuub J M Op den Camp
Feb 3, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C V F BatistaL D Possani
Jun 26, 2020·Toxicon : Official Journal of the International Society on Toxinology·Allanny Alves FurtadoMatheus de Freitas Fernandes-Pedrosa
Jan 18, 2018·Toxicon : Official Journal of the International Society on Toxinology·C V F BatistaL D Possani
Jul 31, 2018·Toxicon : Official Journal of the International Society on Toxinology·Marie-France Martin-EauclaireMaria Elena de Lima
Aug 12, 2008·The Journal of Experimental Biology·Denise Cavalcante HissaVânia Maria Maciel Melo
Apr 28, 2004·Toxicon : Official Journal of the International Society on Toxinology·Adolfo BorgesStefan H Heinemann
Oct 9, 2007·Toxicon : Official Journal of the International Society on Toxinology·Adolfo BorgesCarlos Chávez-Olórtegui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.