Toxic potential of microcystin-containing cyanobacterial extracts from three Romanian freshwaters

Toxicon : Official Journal of the International Society on Toxinology
Daniela Alina BoaruKristin Schirmer

Abstract

The aim of this study was to characterise for the first time the toxin profile and in vivo/in vitro toxicological effects of cyanobacteria obtained from three Romanian freshwater blooms. Two strains of Microcystis aeruginosa were isolated from blooms occurring in different fish ponds. As well, a complex bloom sample obtained from a recreational lake area and dominated by Microcystis aeruginosa and Microcystis viridis was explored. The morphological identity of the cyanobacterial species could be confirmed by sequence analysis of the intergenic spacer region of the phycocyanin operon, PC-IGS. As well, both the strains and the field sample were confirmed to possess mcyA and mcyB genes, which correlated with the formation of several microcystins (MCYSTs). A number of cyanopeptolins and a new aeruginosin were also found. Despite these mixtures of compounds, in vivo as well as in vitro toxicological responses resembled those previously found for MCYST-LR. These include strong hepatotoxicity in mice with parenchymal disintegration and the emergence of haemorrhagic centres, a lack of responsiveness of human and fish cell lines most likely due to a lack of active transport systems, and a significant subcellular damage most prominent on...Continue Reading

References

Mar 1, 1990·FEMS Microbiology Letters·C MartinJ Weckesser
Aug 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·K E FladmarkS O Døskeland
Jun 29, 1999·Journal of Bacteriology·B A NeilanT Börner
May 30, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R J Gonzalez, J B Tarloff
Jan 5, 2002·Applied Microbiology and Biotechnology·E DittmannT Börner
Sep 23, 2003·Environmental Toxicology·Valérie Fessard, Cécile Bernard
Apr 5, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ivanka TenevaKristin Schirmer
Oct 8, 2009·Analytica Chimica Acta·Milla-Riina NefflingJussi Meriluoto

❮ Previous
Next ❯

Citations

Mar 29, 2012·Canadian Journal of Microbiology·Jing Ping ZhuXian Li
Dec 14, 2007·Angewandte Chemie·Karolina ErsmarkStephen Hanessian
Mar 13, 2021·Toxicon : Official Journal of the International Society on Toxinology·Kamila ŠrédlováTomáš Cajthaml
May 1, 2018·Toxicon : Official Journal of the International Society on Toxinology·Arevik MinasyanAnastasia Hiskia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.