Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona)

Environmental Science and Pollution Research International
Sofia R MesquitaBenjamin Piña

Abstract

Atmospheric particulate matter (PM) is a recognized risk factor contributing to a number of diseases in human populations and wildlife globally. Organic matter is a major component of PM, but its contribution to overall toxicity of PM has not been thoroughly evaluated yet. In the present work, the biological activity of organic extracts from PM1 (particles with less than 1 μm of aerodynamic diameter) collected from an urban road site in the centre of Barcelona (NE Spain) was evaluated using a yeast-based assay (AhR-RYA) and different gene expression markers in zebrafish embryos. Dioxin-like activity of the extracts correlated to primary emissions from local traffic exhausts, reflecting weekday/weekend alternance. Expression levels of cyp1a and of gene markers for key cellular processes and development (ier2, fos) also correlated to vehicle emissions, whereas expression of gene markers related to antioxidant defence and endocrine effects (gstal, hao1, ttr) was strongly reduced in samples with strong contribution from regional air masses with aged secondary organic species or with strong influence of biomass burning emissions. Our data suggest that the toxic potential of PM1 organic chemical constituents strongly depends on the e...Continue Reading

References

Dec 1, 1992·Regulatory Toxicology and Pharmacology : RTP·I C Nisbet, P K LaGoy
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Jan 14, 2003·Annual Review of Physical Chemistry·John H Seinfeld, James F Pankow
Feb 11, 2004·Environmental Toxicology and Chemistry·Rebecca J SheesleyJames J Tortorelli
Jun 19, 2004·Inhalation Toxicology·Chrysanthus J ObotAndrij Holian
Mar 19, 2005·Environmental Science & Technology·Rebecca J SheesleyMiel A Barman
Aug 27, 2005·Carcinogenesis·Paolo Vineis, Kirsti Husgafvel-Pursiainen
Aug 2, 2007·Environmental Toxicology and Chemistry·Kentaro MisakiTomonari Matsuda
Oct 17, 2007·Environmental Science & Technology·Zhi NingConstantinos Sioutas
Jun 26, 2008·Environmental Science and Pollution Research International·Stefan ScholzDoris Voelker
Oct 31, 2008·Talanta·Tania-Noelia NoguerolBenjamin Piña
Jan 23, 2010·Environmental Science & Technology·Annina GaschenMarianne Geiser
Jan 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sanne A B HermsenAldert H Piersma
Apr 2, 2013·Environmental Pollution·Alba OlivaresBenjamin Piña
Mar 7, 2014·Environmental Science and Pollution Research International·Sofia Raquel MesquitaBenjamin Piña
Sep 30, 2014·Diabetes Research and Clinical Practice·Eric V BaltiAndre P Kengne
Jun 10, 2015·Journal of Chromatography. a·Marta FontalJoan O Grimalt
Aug 25, 2015·Environmental Pollution·Sofia R MesquitaBenjamin Piña
Jan 9, 2016·The Science of the Total Environment·Sofia R MesquitaBenjamin Piña

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Citations

Oct 21, 2017·International Journal of Environmental Research and Public Health·Pieter Jan KoleAd M J Ragas
Sep 9, 2019·Environmental Science and Pollution Research International·Mariola BrinesBarend L van Drooge
Apr 16, 2019·Chemosphere·Angélica Guerrero-CastillaDavid A Jones

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