May 24, 2020

Toxic potentials of particulate and gaseous air pollutant mixtures and the role of PAHs and their derivatives

Environment International
Zuzana NovákováKlára Hilscherová

Abstract

Air pollution, which represents a major environmental risk to human health, comprises a complex mixture of compounds where only little is known about its specific toxicities. This study examined the specific toxicities associated with ambient air pollutant mixtures with respect to gas/particle partitioning, particulate matter (PM) size, pollutant polarity and bioaccessibility from PM, and evaluated the contribution of PAHs and their oxygenated and nitrated derivatives (OPAHs, NPAHs). Air samples (gas phase, PM10 and size-segregated PM), were collected at urban (in winter and summer) and background (winter) sites in the Czech Republic. The total and bioaccessible concentrations were addressed using organic solvent extraction and simulated lung fluid extraction, respectively. Organic extracts were also further fractionated according to polarity. Aryl hydrocarbon receptor (AhR)-mediated activity, anti-/estrogenicity, anti-/androgenicity, thyroid receptor (TR)-mediated activity and cytotoxicity for bronchial cells were determined by human cell-based in vitro bioassays. The contribution of studied compounds to observed effects was assessed by both modelling and reconstructing the mixtures. Significant effects were detected in the su...Continue Reading

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Mentioned in this Paper

OpaH protein, Neisseria gonorrhoeae
Androgenization
Environment
Pollutant
Reconstructive Surgical Procedures
Polycyclic Hydrocarbons, Aromatic
Toxic Effect
Site
Cellular Assay
Aryl Hydrocarbon Receptor

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