PMID: 9182503Jan 1, 1997Paper

Toxic properties of recombinant tumor necrosis factor

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
V I MasychevaN M Pustoshilova

Abstract

Toxic properties of recombinant human tumor necrosis factor (TNF-beta) were studied on noninbred albino mice. In the maximum tolerable doses the preparation induced a decrease in the body weight and temperature of the animals as well as development of glyco- and leukopenic reactions and damage of the internal organ structures. The preparation effects were observed early after the exposure and were mainly reversible. The most TNF-beta sensitive organs were the liver, lungs, adrenal gland, thymus and spleen. The major link in the pathological process development under the effect of the TNF-beta toxic doses was likely increased intravascular blood coagulability evident from a marked procoagulant activity of the preparation.

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