Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure

Toxicology
M D StoutJ R Bucher

Abstract

Methyl isobutyl ketone (MIBK) is primarily used as a denaturant for rubbing alcohol, as a solvent and in the manufacture of methyl amyl alcohol. Inhalation of vapors is the most likely route of exposure in the work place. In order to evaluate the potential of MIBK to induce toxic and carcinogenic effects following chronic exposure, groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MIBK at concentrations of 0, 450, 900, or 1800ppm by inhalation, 6h/day, 5 days per week for 2 years. Survival was decreased in male rats at 1800ppm. Body weight gains were decreased in male rats at 900 and 1800ppm and in female mice at 1800ppm. The primary targets of MIBK toxicity and carcinogenicity were the kidney in rats and the liver in mice. In male rats, there was increased mineralization of the renal papilla at all exposure concentrations. The incidence of chronic progressive nephropathy (CPN) was increased at 1800ppm and the severity was increased in all exposed groups. There were also increases in renal tubule hyperplasia at all exposure concentrations, and in adenoma and adenoma or carcinoma (combined) at 1800ppm; these lesions are thought to represent a continuum in the progression of proliferative lesions in rena...Continue Reading

References

Jan 1, 1992·Environmental and Molecular Mutagenesis·E ZeigerK Mortelmans
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·S J BorghoffJ A Swenberg
Aug 1, 1990·Canadian Journal of Physiology and Pharmacology·M VézinaG L Plaa
Oct 1, 1986·Molecular and Cellular Biology·J I MacInnesD T Kurtz
Jan 1, 1989·Toxicology and Applied Pharmacology·J A SwenbergM Charbonneau
May 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C J Portier, A J Bailer
Oct 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R D PhillipsJ O'Donoghue
Sep 1, 1974·CRC Critical Reviews in Toxicology·R Schulte-Hermann
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·L ShenkmanC S Hollander
Nov 1, 1995·Journal of Toxicology and Environmental Health·P Raymond, G L Plaa
Aug 1, 1995·Journal of Toxicology and Environmental Health·P Raymond, G L Plaa
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gordon C Hard
Jun 19, 2004·International Journal of Toxicology·M D NemecS B Harris
Jun 15, 2007·Toxicologic Pathology·Adriana M DoiJohn R Bucher

❮ Previous
Next ❯

Citations

Sep 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Shakil A Saghir, David L Rick
Oct 12, 2010·Pharmaceutical Statistics·Ludwig A Hothorn, Gemechis D Djira
Jan 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayman S BannagaRamesh P Arasaradnam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.