Toxicity and carcinogenicity studies of oxazepam in the Fischer 344 rat

Toxicological Sciences : an Official Journal of the Society of Toxicology
J R BucherM J Ryan

Abstract

Oxazepam and related benzodiazepines are used in the treatment of anxiety. Carcinogenicity studies of oxazepam were performed with the F344 rat because of marked differences in tumor responses observed in NTP studies with B6C3F1 and Swiss-Webster mice compared to the results of Sprague-Dawley rat studies submitted to the FDA by a manufacturer to support registration of the drug. Groups of 50 male and 50 female F344/N rats were fed diets containing 0, 625, 2500, or 5000 ppm oxazepam for up to 105 weeks. A stop-exposure group of 50 males and 50 females received 10,000 ppm oxazepam in diet for 26 weeks, after which animals received control diet. All 5000- and 10, 000-ppm stop-exposure males died before the end of the study. Survival of 2500-ppm males and females was lower than that of controls. Body weight gains of 2500- and 5000-ppm males and females were less than those of controls. Male rats exposed to 2500 ppm had an increased incidence of renal tubule adenoma and hyperplasia. In addition, the incidences of renal tubule adenoma and hyperplasia were increased in the 10,000-ppm stop-exposure group. The incidences of nephropathy in exposed females were greater than those in controls, and the severity of nephropathy increased in e...Continue Reading

Citations

Sep 13, 2008·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yoshimitsu SakamotoAkio Ogata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M C RhodesRajendra S Chhabra
Toxicological Sciences : an Official Journal of the Society of Toxicology
Rajendra S ChhabraR A Renne
© 2022 Meta ULC. All rights reserved