Toxicity and characterization of cholinesterase-inhibition induced by diisopropyl fluorophosphate in Artemia salina larvae

Ecotoxicology and Environmental Safety
S Sánchez-Fortún, M V Barahona

Abstract

The acute toxicity of diisopropyl fluorophosphate (DFP) on three age classes of Artemia salina was evaluated. An increase in toxicity of this organophosphorous (OP) compound was found following longer development of A. salina larvae. The effects of pretreatment with the non-selective muscarinic antagonist atropine, the two reversible acetylcholinesterase inhibitors physostigmine and pyridostigmine, and the cholinesterase-reactivating oxime 2-pyridine aldoxime methoiodide (2-PAM), as individual and combined pretreatments, on DFP-induced lethality in 24h Artemia were also investigated. The lethal action of DFP was not prevented by pretreatment of 24h Artemia with atropine, physostigmine, and pyridostigmine, while 2-PAM proved effective against intoxication with this OP compound. The inhibitory effects of combinations of atropine (10(-5)M) plus 2-PAM or physostigmine were greater than those elicited by either drug alone, with the maximum protection afforded being 100%. Pretreatment with 2-PAM (10(-6)M) plus physostigmine or pyridostigmine was ineffective. These results suggest that the combinations of atropine plus 2-PAM or physostigmine are effective in the prevention of the lethal effects induced by DFP in A. salina larvae.

References

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Citations

Nov 7, 2013·International Journal of Molecular Sciences·George Mihai NitulescuOctavian Tudorel Olaru
Oct 29, 2010·Journal of Applied Toxicology : JAT·Dietrich E LorkeGeorg A Petroianu
Apr 25, 2016·Bulletin of Environmental Contamination and Toxicology·P DvorakM Tomko
Nov 7, 2019·Basic & Clinical Pharmacology & Toxicology·Anne Suély Pinto SavallSimone Pinton
Jul 22, 2018·Journal of Applied Toxicology : JAT·Dietrich E Lorke, Georg A Petroianu

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