Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group.

Journal of Toxicology and Environmental Health. Part a
Diego FigueroaCarlos García

Abstract

Okadaic acid-group (OA-group) is a set of lipophilic toxins produced only in seawater by species of the Dinophysis and Prorocentrum genera, and characterized globally by being associated with harmful algal blooms (HABs). The diarrhetic shellfish poisoning toxins okadaic acid (OA) and dinophysistoxin-1 (DTX-1) are the most prevalent toxic analogues making up the OA-group, which jeopardize environmental safety and human health through consumption of hydrobiological organisms contaminated with these toxins that produce diarrhetic shellfish poisoning (DSP) syndrome in humans. Consequently, a regulatory limit of 160 μg of OA-group/kg was established for marine resources (bivalves). The aim of this study was to investigate effects varying concentrations of 1-15 μg/ml OA or DTX-1 on toxicity, development, and oxidative damage in zebrafish larvae (Danio rerio). After determining the lethal concentration 50 (LC50) in zebrafish larvae of 10 and 7 μg/ml (24 h) and effective concentration 50 (EC50) of 8 and 6 μg/ml (24 h), different concentrations (5, 6.5, or 8 μg/ml of OA and 4, 4.5, or 6 μg/ml of DTX-1) were used to examine the effects of these toxins on oxidative damage to larvae at different time points between 24 and 120 hpf. Macrosco...Continue Reading

References

Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Oct 8, 2003·Current Medicinal Chemistry·Masayasu InoueKozo Utsumi
Mar 27, 2007·Toxicon : Official Journal of the International Society on Toxinology·Nicolas EscoffierMarc Edery
Jul 1, 2008·Toxicon : Official Journal of the International Society on Toxinology·L AtencioA M Cameán
Dec 10, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Iskra A SignoreMiguel L Concha
Jun 29, 2011·Journal of Toxicology and Environmental Health. Part a·Vanessa ValdiglesiasJosefina Méndez
Jul 20, 2011·Nature Chemical Biology·Bryan C Dickinson, Christopher J Chang
Dec 2, 2011·Environmental Monitoring and Assessment·Yao ChenYu-Feng Cao
Jan 27, 2012·Free Radical Research·Miral Dizdaroglu, Pawel Jaruga
Apr 26, 2012·Environmental Science and Pollution Research International·Jocelyne HellouThomas W Moon
May 16, 2012·Chemosphere·Cleoni dos Santos CarvalhoMarisa Narciso Fernandes
Aug 15, 2012·Redox Report : Communications in Free Radical Research·Yannis V SimosAngelos M Evangelou
Nov 28, 2012·Journal of Visualized Experiments : JoVE·Avdesh AvdeshRalph N Martins
Jun 13, 2013·Journal of Cancer Research and Clinical Oncology·Hirota FujikiMasami Suganuma
Jan 23, 2014·Marine Drugs·Beatriz RegueraJuan Blanco
Mar 19, 2014·Environmental Toxicology and Pharmacology·Nai-sheng ZhangWei-dong Yang
Jul 5, 2015·Journal of Environmental Sciences (China)·M Martínez-SalesF J Espinós
Jul 15, 2015·Journal of Toxicology and Environmental Health. Part a·María Verónica Prego-FaraldoJosefina Méndez
May 7, 2016·Toxins·Kamalakar ChatlaLarry A Hanson
Sep 21, 2016·Journal of Toxicology and Environmental Health. Part a·Stacy WolffKristine L Willett
Nov 1, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Carlos GarcíaHéctor R Contreras
Dec 13, 2016·Environmental Science and Pollution Research International·Yanhua WangYijun Yu
Jan 12, 2017·Harmful Algae·Patricio A DíazBeatriz Reguera
Sep 12, 2017·Journal of Toxicology and Environmental Health. Part a·Flavia R AbeDanielle P de Oliveira
Dec 24, 2017·Environmental Toxicology and Chemistry·Lauren A KristofcoBryan W Brooks
Feb 1, 2018·Marine Drugs·Jimmy AlarcanValérie Fessard
Feb 11, 2018·Toxicon : Official Journal of the International Society on Toxinology·Ghada SouidKhira Maaroufi
Mar 2, 2018·The Journal of Veterinary Medical Science·Hodaka Suzuki, Yumiko Okada
Jul 1, 2018·Toxins·Linda TschirrenConstanze Pietsch
Jul 25, 2018·Chemosphere·Sabrina Loise de Morais CaladoHelena Cristina Silva de Assis

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Citations

Oct 6, 2020·Journal of Toxicology and Environmental Health. Part a·Ping Li, Zhi-Hua Li
Oct 20, 2020·Journal of Toxicology and Environmental Health. Part a·Valeska Toffolo MinskiAnna Maria Siebel
Nov 5, 2020·Journal of Toxicology and Environmental Health. Part a·Ola WaselJennifer L Freeman

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