PMID: 6412401Jun 1, 1983Paper

Toxicity and distribution in chick embryos of 3,3',4,4'-tetrachlorobiphenyl injected into the eggs

Toxicology
B Brunström, P O Darnerud

Abstract

3,3',4,4'-Tetrachlorobiphenyl (3TCB) was injected into the yolk of embryonated hens' eggs in doses of 4, 20 or 100 micrograms/kg egg. Twenty and 100 micrograms/kg resulted in the death of all the embryos. The hatching rate of the eggs treated with 4 micrograms/kg was 60% while that of the control eggs was 88%. This means that 3TCB is at least 10 000 times more toxic in chick embryos than a previously studied isomer, 2,2',4,5'-tetrachlorobiphenyl (2TCB). 3,3',4,4'-Tetrachlorobiphenyl might be teratogenic in chick embryos since eye and beak deformities were seen in 3 unhatched tetrachlorobiphenyl-treated embryos. In addition rump edema and excess fluid in the body cavity was observed in some embryos. The distribution of the 2 tetrachlorobiphenyls in chick embryos was studied by means of whole-body autoradiography. No differences in distribution, which could explain the extreme difference in toxicity, were detected. High amounts of radioactivity were found in the bile of the embryos, indicating a capacity of the embryos to metabolize and excrete the tetrachlorobiphenyls.

References

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Citations

Nov 5, 2004·Archives of Toxicology·Krister HalldinBjörn Brunström
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B Brunström, K Halldin
Aug 1, 1991·Journal of Toxicology and Environmental Health·M J Mac, C C Edsall
Mar 1, 1996·Pharmacology & Toxicology·P O DarnerudC J Jönsson
Dec 22, 2007·Asian Journal of Andrology·Xiu-Mei JinZan-Dong Li
Oct 13, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Maria E JönssonBjörn Brunström
Aug 11, 2004·General and Comparative Endocrinology·Ryo KamataMasatoshi Morita
May 11, 2006·Drug Metabolism Reviews·Heather M H Goldstone, John J Stegeman
Apr 8, 2015·Colloids and Surfaces. B, Biointerfaces·Agnese BlandinoLuca Santi
Nov 4, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica C HervéSean W Kennedy
Jan 1, 1993·Critical Reviews in Toxicology·R E PetersonG L Kimmel
Apr 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P O DarnerudG O Sperber
Feb 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T SinjariP O Darnerud
Feb 1, 2003·Current Protocols in Toxicology·Diane S HenshelAndrea Troutman
Nov 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Elvis Genbo XuNathalie Tufenkji

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