Toxicity and dose response of intra-abdominally administered poly-L-alpha-lysine and poly-L-glutamate for postoperative adhesion protection

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
K IsakssonBobby Tingstedt

Abstract

Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. 152 mice were investigated with a well-known adhesion model and given different concentrations of the two differently charged polypeptides as well as only the cationic PL. For the first time, a probable toxic level of PL given intraperitoneally (40 mg/kg) and the lowest significant concentration of PL and PG for antiadhesive purposes (1.6 mg/kg) could be established. The gap between the possible toxicity level of PL and the lowest efficient antiadhesive dose is probably too narrow, and the shape and charge of PL warrant continuous research for another polycation in the concept of differently charged polypeptides used as antiadhesive agents.

Citations

Oct 24, 2013·International Journal of Medical Sciences·D ÅkerbergB Tingstedt
Jan 23, 2014·Journal of Materials Science. Materials in Medicine·K IsakssonB Tingstedt
Oct 13, 2012·Current Problems in Surgery·Merril T DaytonAlan R Posner
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Apr 15, 2011·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Louis G Castonguay

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