Toxicity and postwithdrawal effects of ketamine on the reproductive function of male albino rats: Hormonal, histological, and immunohistochemical study.

Human & Experimental Toxicology
M G PaulisN F El-Tahawy

Abstract

Ketamine is increasingly used in clinical practice, and ketamine addiction is common in young individuals. There are limited reviews on the chronic effects of ketamine on the testes. Three groups of rats received saline or ketamine 50 mg/kg/day intraperitoneally for 6 weeks with or without a subsequent 4-week drug-free period. Serum follicle-stimulating hormone, luteinizing hormone, prolactin, and testosterone levels, as well as testicular malondialdehyde concentrations, were measured. Epididymal sperm parameters were assessed. Testicular tissues were examined by hematoxylin and eosin staining and immunohistochemical staining using caspase-3 and vimentin antibodies. Chronic ketamine injection significantly decreased the levels of the examined hormones and adversely affected sperm parameters. Testicular tissue showed a significant increase in caspase-3 expression. In addition, Sertoli cell shape and position were disrupted. These effects disappeared 4 weeks after drug withdrawal. Chronic ketamine treatment has revisable hazardous effects on the rat reproductive function. There is a need to increase the knowledge of physicians and the public regarding these harmful effects of ketamine.

References

Mar 23, 2000·Pharmacology & Toxicology·M DalgaardO Ladefoged
Oct 11, 2001·American Journal of Physiology. Renal Physiology·E NoiriM S Goligorsky
Dec 12, 2001·Reproductive Toxicology·N M BiswasM Sarkar
Apr 27, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Yen-Chieh WangChih-Ming Lin
Jul 16, 2010·Journal of Comparative Pathology·B BancoV Grieco
May 13, 2011·Microscopy Research and Technique·Sijie TanD T Yew
Feb 23, 2012·Human & Experimental Toxicology·M S M WaiD T Yew
Jan 29, 2013·Journal of Assisted Reproduction and Genetics·Fatma AtigMounir Ajina
Feb 7, 2013·Human & Experimental Toxicology·Y KalkanA Turan
Aug 15, 2013·Life Sciences·Carlos VenâncioFrancisco Peixoto
Jan 1, 2011·Emerging Health Threats Journal·Sarbjeet S KalsiPaul I Dargan
Dec 10, 2013·Toxicology and Industrial Health·Ramazan UygurOguz Aslan Ozen
Jul 3, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gustavo VasenPatricia S Cuasnicú
Jul 23, 2015·British Journal of Anaesthesia·T T DongA W Gelb
Jul 29, 2015·Seizure : the Journal of the British Epilepsy Association·Yao Fang, Xuefeng Wang
Aug 8, 2015·Pediatric Emergency Care·Jessica W WangLaurie Gordon
Jan 30, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carlo PancaroJames E Marchand
Feb 6, 2016·Andrology·L R FrançaM D Griswold
Apr 10, 2016·Seminars in Cell & Developmental Biology·Pranitha JenardhananPremendu P Mathur
Aug 12, 2016·Reproduction, Fertility, and Development·Wannisa Sukhorum, Sitthichai Iamsaard
Jul 5, 2017·International Neurourology Journal·Chi-Hang YeeChi-Fai Ng
Jul 28, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Yiyan WangHaolin Chen
Jan 18, 2018·Neuropharmacology·I Ivan Ezquerra-RomanoC J A Morgan
Feb 13, 2018·Biochemical and Biophysical Research Communications·Hamdy A A Aly, Memy H Hassan
Jun 22, 2018·Regional Anesthesia and Pain Medicine·Jose L ZeballosJames P Rathmell
Nov 18, 2018·British Journal of Anaesthesia·K Hirota, D G Lambert
Feb 24, 2019·Biotechnology Advances·Antonio L Grilo, Athanasios Mantalaris
Oct 16, 2019·Experimental and Molecular Pathology·Juanita BustamanteSilvia Lores-Arnaiz

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Citations

Mar 19, 2021·Drug Design, Development and Therapy·Hulya KasıkaraMustafa Kavutcu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
MDA
dissection

Software Mentioned

ImageJ
SPSS

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