Toxicity and tumorigenicity of purpurin, a natural hydroxanthraquinone in rats: induction of bladder neoplasms

Cancer Letters
H MoriK Kawai

Abstract

Chronic toxicity and tumorigenicity of purpurin, a natural hydroxyanthraquinone, was examined in two groups of male F344 rats. One group was given a basal diet mixed with purpurin at a concentration of 1% throughout the experiment (520 days). Another group was kept on the basal diet without purpurin during the experiment. Almost all animals given purpurin developed conspicuous changes of kidney resembling 'progressive chronic nephropathies', the severity and frequency of which were much stronger than in controls. In rats with purpurin treatment, marked hyperplasia of pelvic epithelium was frequently seen and several rats developed urinary bladder tumors (papilloma and carcinoma). Prominent crystallization in the renal pelvis and urinary bladder seems to be initially related to the toxic effects of this hydroxanthraquinone on the renal tubules and with the occurrence of epithelial hyperplasia and neoplasms.

Citations

Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Banasri HazraUtpal Sanyal
Aug 12, 2015·International Journal of Molecular Sciences·Atsushi FurutaNaohiro Noda
Nov 27, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kaoru InoueAkiyoshi Nishikawa
Apr 22, 2005·Mutagenesis·Sakae Arimoto-KobayashiAkie Yamaguchi
Dec 1, 2020·Phytotherapy Research : PTR·Jyoti SinghAbha Meena
May 15, 2003·Journal of Agricultural and Food Chemistry·Tim MarczyloHikoya Hayatsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Gilles-Eric SéraliniJoël Spiroux de Vendômois
Journal of Applied Toxicology : JAT
D G SerotaS C Gad
© 2021 Meta ULC. All rights reserved