PMID: 16639893Apr 28, 2006Paper

Toxicity assessment of environmentally relevant pollutant mixtures using a heuristic model

Integrated Environmental Assessment and Management
Allen W Olmstead, Gerald A Leblanc

Abstract

In this study, 9 chemicals were chosen from a recent report on surface water concentrations of a variety of xenobiotics to test the hypothesis that the toxicity of chemical mixtures could be estimated using a model based on the toxicity of the individual chemicals. Concentration-response curves for the endpoints of lifespan, growth rate, and fecundity were generated for each chemical experimentally using the crustacean, Daphnia magna. From this data, a mathematical model for the combined toxicity of these chemicals was generated that merged the concepts of concentration addition and independent joint action. Toxicity of a mixture was modeled at various levels at which the ratio of the chemicals within the mixture was maintained at that reported for median detected environmental levels. Toxicity of the mixture was then determined experimentally and compared to model predictions. The model accurately predicted the most sensitive endpoint, as well as the lowest toxic effect level of the mixture. Results demonstrated that, for this mixture of chemicals, toxicity was not influenced significantly by interactions among the chemicals and a single constituent dominated toxicity. According to model predictions and experimental results, t...Continue Reading

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Jun 5, 2003·Environmental Health Perspectives·Allen W Olmstead, Gerald A LeBlanc

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Citations

Feb 23, 2010·Environmental Science and Pollution Research International·Abel L G FerreiraSusana Loureiro
Dec 5, 2013·Computational Intelligence and Neuroscience·Christian LebiereJohn R Anderson
Dec 19, 2009·Environmental Health Perspectives·Marcelo J WolanskyKevin M Crofton
Sep 17, 2010·Ecotoxicology and Environmental Safety·Maria D PavlakiAmadeu M V M Soares
Oct 30, 2007·Aquatic Toxicology·Hans SandersonKeith Solomon
Mar 12, 2016·Environmental Science and Pollution Research International·Xiangyang WuLiuqing Yang
Sep 18, 2015·The Science of the Total Environment·C Becouze-LareureY Perrodin
Jan 22, 2008·International Journal of Andrology·Cynthia V RiderL Earl Gray
Aug 19, 2007·Environmental Toxicology·A D Evans, M Nipper
Sep 21, 2011·Integrated Environmental Assessment and Management·Wayne G Landis, Peter M Chapman
Dec 25, 2010·Integrated Environmental Assessment and Management·Scott DyerBeate I Escher
Sep 8, 2010·Environmental Toxicology and Chemistry·Susana LoureiroAmadeu M V M Soares
Sep 14, 2011·Integrated Environmental Assessment and Management·Dallas AronsonPhilip H Howard
Sep 19, 2012·Integrated Environmental Assessment and Management·Wayne G Landis
Dec 16, 2011·Environmental Toxicology and Chemistry·Greg L SaylorMargaret J Kupferle
Jun 19, 2012·Integrated Environmental Assessment and Management·Francisco Sánchez-Bayo
Sep 30, 2005·Aquatic Toxicology·Allen W Olmstead, Gerald A Leblanc
Dec 31, 2014·TheScientificWorldJournal·Maria AdamkovicovaHana Duranova
May 2, 2015·Environmental Science and Pollution Research International·Li-Tang QinYan-Peng Liang
Mar 10, 2015·Chemosphere·Namrata SenguptaWilliam S Baldwin
Aug 27, 2013·The Science of the Total Environment·Laurie S Balistrieri, Christopher A Mebane
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Jul 16, 2017·The Science of the Total Environment·Simone HasenbeinRichard E Connon
Dec 12, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elizabeth Medlock KakaleyVickie S Wilson
Jul 9, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cynthia V Rider, Gerald A LeBlanc
Oct 7, 2005·Pharmacogenomics·John C LindonJeremy K Nicholson
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Jul 21, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cynthia V Rider, Gerald A LeBlanc
Oct 27, 2017·Nutrition Reviews·S Setareh SanjariYasemin Boztug

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