Toxicity comparison of chlorinated and brominated dibenzo-p-dioxins and dibenzofurans in industrial source samples by HRGC/HRMS and enzyme immunoassay

Environment International
Fatin SamaraBrian K Gullett

Abstract

Limited information is available on the applicability of polychlorinated dibenzo-p-dioxin/furan (PCDD/F) toxicity assays to their brominated counterparts: polybrominated dibenzo-p-dioxins/furans (PBDDs/Fs). We estimated the toxicity of mixtures of chlorinated, brominated, and mixed bromochloro-dioxins and -furan (PBCDDs/Fs) laboratory standards using a chemically-activated luciferase gene expression cell bioassay (CALUX). The relative effects potency (REP) values obtained were comparable to the World Health Organization (WHO) toxic equivalency factors (TEFs) and in agreement with the concept of additive congener toxicity of mixtures of dioxins and furans. Enzyme immunoassay (EIA)-based toxic equivalents (TEQs), however, showed overestimation for PCDDs/Fs (0-4 orders of magnitudes higher) and underestimation for PBDDs/Fs (0-1 orders of magnitude lower) when compared to high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS)-based TEQ calculation (using WHO TEFs) in samples from an industrial source line. No correlation was found between the EIA and the HRGC/HRMS data, which could be attributed to differences in homologue-specific cross-reactivity responses, sample matrix type, and presence of other compo...Continue Reading

References

Feb 21, 1997·Journal of Toxicology and Environmental Health·L W Weber, H Greim
Jul 26, 2003·Food Additives and Contaminants·P LaierA M Vinggaard
Oct 18, 2003·Analytical and Bioanalytical Chemistry·M-C Estévez-Alberola, M-P Marco
Apr 22, 2004·Chemosphere·David J BrownGeorge C Clark
Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson

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Citations

Apr 13, 2013·Environmental Science & Technology·Mohammednoor Altarawneh, Bogdan Z Dlugogorski

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