Toxicity effects of profenofos on embryonic and larval development of Zebrafish (Danio rerio)

Environmental Toxicology and Pharmacology
Rajesh PamanjiJ Venkateswara Rao

Abstract

The aim of the present study was to evaluate the developmental toxicity of profenofos to early developing Zebrafish (Danio rerio) embryos (4h post fertilization) in a static system at 1.0 to 2.25mg/L. Median lethal concentrations (LC50) of profenofos at 24-h, 48-h, 72-h and 96-h were determined as 2.04, 1.58, 1.57 and 1.56 mg/L, respectively. The hatching of embryos were recorded at every 12h interval and the median hatching time (HT50) was also calculated for each concentration. In a separate set of experiments, 96-h LC10 (0.74 mg/L) and LC50 (1.56 mg/L) concentrations were used to assess the developmental toxicity in relation to behavior, morphology, and interactions with the targeted enzyme acetylcholinesterase. Live video-microscopy revealed that the profenofos exposed embryos exhibited an abnormal development, skeletal defects and altered heart morphology in a concentration-dependent manner, which leads to alterations in the swimming behavior of hatchlings at 144-h, which indicate that developing zebrafish are sensitive to profenofos.

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Citations

Feb 27, 2016·Environmental Science and Pollution Research International·Shardendu KumarJuan Francisco Villarreal-Chiu
Jun 14, 2016·Environmental Toxicology and Pharmacology·Rajesh PamanjiJanapala Venkateswara Rao
Jul 1, 2016·Chemical Research in Toxicology·Luís M FélixAna M Coimbra
Jul 1, 2016·Drug Discoveries & Therapeutics·Tanongsak Sassa-DeepaengSiriporn Okonogi
May 26, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Xian T LuJun H Tang
Oct 13, 2017·Zebrafish·Sreeja SarasammaChung-Der Hsiao
Jul 8, 2017·Development·Melissa A PickettNanette M Nascone-Yoder
Feb 9, 2018·Current Environmental Health Reports·Karilyn E Sant, Alicia R Timme-Laragy
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Feb 20, 2019·Environmental Science and Pollution Research International·Sonia GaaiedMohamed Banni
Jun 2, 2021·Journal of Nanobiotechnology·Angélica I S LuisLeonardo F Fraceto

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