Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens

Environmental Science & Technology
Xin HuPeter S Thorne

Abstract

The health risk of inhalation exposure to polychlorinated biphenyls (PCB) cannot be assessed with high confidence due to the lack of rigorous inhalation studies. One uncertainty rests on exposure regimen, as whole-body exposure systems allow oral PCB intake that confounds the exposure. We conducted contemporaneous PCB inhalation exposures with whole-body and nose-only exposure methods. Female Sprague-Dawley rats were concurrently exposed to vapor-phase PCBs (533 ± 93 μg/m(3)) generated from PCB11-supplemented Chicago Air Mixture resembling the Chicago airshed, 4 h/day, 6 days/week, for 4 weeks. Congener-specific analysis showed 1.5-fold higher ∑PCBs in the lungs of nose-only exposed than the whole-body exposed animals (p = 0.0024). Higher ∑PCB concentrations were also found in the sera, livers, brains, and adipose tissue of nose-only exposed animals (1.1-1.5-fold), but these increases were not statistically significant. Congener profiles of five tissue types were dominated by PCB 28/31 and higher-chlorinated congeners in both groups reflecting rapid metabolism of other lower-chlorinated PCBs. No toxicity was seen regarding metabolic enzyme expression, glutathione, or histopathology. However, diminished weight gain and reduced p...Continue Reading

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Jan 13, 2018·Environmental Science and Pollution Research International·Xueshu LiHans-Joachim Lehmler
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Dec 2, 2020·Environmental Science & Technology·Hui WangPeter S Thorne
Dec 2, 2019·The Science of the Total Environment·Wendy J Heiger-BernaysMadeleine K Scammell

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