PMID: 9444316Jan 28, 1998Paper

Toxicity evaluation of petroleum blending streams: reproductive and developmental effects of a distillate from light alkylate naphtha

Journal of Toxicology and Environmental Health. Part a
Q BuiM H Feuston

Abstract

A distillate of light alkylate naphtha (CAS number 64741-66-8; LAN distillate) was administered via inhalation, 6 h/d, 7 d/wk to 4 groups of Sprague-Dawley rats (10/sex/dose) at target concentrations of 0 (filtered air control), 5, 12.5, or 25 g/m3 with the highest dose exceeding 60% of the lower explosive limit of LAND. Exposure began 2 wk prior to mating and continued throughout gestation until postnatal d 4 for females or for 8 consecutive weeks for males. No apparent clinical signs indicative of systemic toxicity were observed in the F0 and F1 animals of either sex. Inhalation exposure to LAND up to and including the 25 g/m3 dose level had no effect on parental food consumption, body weights, absolute and relative organ weights, and reproductive indices. All groups had comparable delivery data and a fertility index > or 80%. Pups in all groups showed comparable birth weights, weight gain, a viability index (postnatal d 4) for all groups of > or = 97%, and no histopathological changes. In the dams, there were no significant differences in the mean numbers of corpora lutea, implantation sites, and resorptions recorded at necropsy. In the males, the only remarkable findings at necropsy were a small right epididymis and testis ...Continue Reading

Citations

Jan 10, 2002·Reproductive Toxicology·L RobertsP Newton
May 16, 2006·Toxicology·Roberta Lo PumoFilippo Drago
Apr 15, 2015·Critical Reviews in Toxicology·Richard H MckeeJuan-Carlos Carrillo
Sep 13, 2013·Regulatory Toxicology and Pharmacology : RTP·Charles R ClarkPatrick W Beatty
Jun 24, 2014·Regulatory Toxicology and Pharmacology : RTP·Derek SwickHerb Estreicher
Nov 2, 2013·International Journal of Toxicology·Richard H McKeeLinda Roberts

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