Toxicity of 2,3-dialkyl-1,4-naphthoquinones in rats: comparison with cytotoxicity in vitro

Free Radical Biology & Medicine
R MundayC M Munday

Abstract

The short-term toxicities of 2-methyl-1,4-naphthoquinone and a series of 2,3-dialkyl-1,4-naphthoquinones have been determined in rats and compared with their ability to cause oxidative damage to erythrocytes in vitro. In accord with previous results, 2-methyl-1,4-naphthoquinone caused marked oxidative damage to erythrocytes in vitro and haemolytic anaemia in rats. The dialkylnaphthoquinones were also haemolytic agents in vivo, with 2,3-dimethyl-1,4-naphthoquinone being particularly active. Unlike the monoalkyl derivative, however, these substances caused little or no damage to red cells in vitro. The in vivo toxicity of dialkylnaphthoquinones cannot, therefore, be predicted on the basis of in vitro cytotoxicity tests.

References

Jan 1, 1991·Chemico-biological Interactions·P J O'Brien
Apr 1, 1991·Journal of Applied Toxicology : JAT·R MundayE A Fowke
Apr 1, 1986·Biochemical Pharmacology·M G MillerG M Cohen
Jan 1, 1989·Free Radical Biology & Medicine·G Powis
Jan 1, 1989·Chemico-biological Interactions·M Comporti
Jan 1, 1989·Free Radical Biology & Medicine·A Brunmark, E Cadenas
Jul 1, 1970·Toxicology and Applied Pharmacology·R K MorrisonD A Cooney
Jul 1, 1968·Toxicology and Applied Pharmacology·J F Schmedtje, W Andrew
May 15, 1981·European Journal of Biochemistry·S G CondòM Brunori
Jan 1, 1994·Free Radical Biology & Medicine·C GiuliviK J Davies
Jun 1, 1993·Experimental Cell Research·W MalorniS W Peterson
Jul 1, 1964·Biochemistry·G COHEN, P HOCHSTEIN
Feb 1, 1993·Parasitology Today·A T Hudson

❮ Previous
Next ❯

Citations

Nov 17, 1995·Chemico-biological Interactions·R MundayC M Munday
Dec 4, 2004·Chemical & Pharmaceutical Bulletin·Rodrigo Rezende KitagawaWagner Vilegas
Sep 22, 2009·European Journal of Pharmacology·Syed M QadriFlorian Lang
Jan 15, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mohd Shahid Khan, Zahid H Khan
Apr 6, 1999·Chemico-biological Interactions·R MundayC M Munday
Jul 12, 2008·Phytochemistry·Rodrigo R KitagawaMaria Stella G Raddi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.