PMID: 9447228Feb 3, 1998Paper

Toxicity of a new antismoking mouthwash 881010 in rats and rabbits

Journal of Toxicology and Environmental Health. Part a
S O TamimiA S Salhab

Abstract

Male and female rats and rabbits were used in this study to investigate the acute and subchronic toxicity of a new antismoking (A.S.) mouth wash (0.5% silver nitrate as the active ingredient). The LD50 values for i.p. administration in male and female rats were 35.7 and 37.2 mg/kg body weight, respectively. The corresponding values in male and female rabbits were 113 and 128 mg/kg body weight, respectively. The oral LD50 values of the mouthwash in male and female rats were 428 and 433 mg/kg body weight, respectively. The corresponding values in male and female rabbits were 1261 and 1320 mg/kg body weight, respectively. Postmortem and histopathological examination revealed congestion, edema, hemorrhage, and mucosal necrosis with brown pigment deposition in the upper gastrointestinal and respiratory tracts for the orally treated animals and ascitis, peritoneal fat necrosis, and pigment deposition in i.p. administered animals. Subchronic toxicity involved administration of low (1.5 mg/kg), intermediate (15 mg/kg), and high (150 mg/kg) doses of A.S. mouthwash by swabbing the oral cavity daily for 30 consecutive days. Body weight, hematologic observations, and histopathological examination showed no significant differences between c...Continue Reading

Citations

Nov 16, 2013·Regulatory Toxicology and Pharmacology : RTP·Niels Hadrup, Henrik R Lam
May 24, 2016·Current Eye Research·Maryam Shayani RadBibi Sedigheh Fazly Bazzaz
Jun 28, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert L SprandoMartine Ferguson
Oct 26, 2013·Journal of Diabetes Research·Xin JiangYaqin Qu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved