Toxicity of alumina nanoparticles in the immune system of mice.

Nanomedicine
Huan LiQiao Niu

Abstract

Aim: Alumina nanoparticles (AlNPs) exert toxic effects in several organs. This study aimed to investigate the toxicity of AlNPs to the immune system. Materials & methods: AlNPs distribution was assessed using CRi in vivo fluorescence imaging. Inductively coupled plasma atomic emission spectrometry was used to detect the content of aluminum in the spleen. Cytokines expression was detected in the immune organs and blood of mice. Results & conclusion: AlNPs can accumulate in mice spleen. Superoxide dismutase and glutathione levels decreased, whereas the level of malondialdehyde increased with decreasing particle size. AlNPs exposure caused cytokine level changes in the spleen, thymus and serum, besides causing damage to immune organs and dysfunction of immune cells, leading to abnormal immune-related cytokine expression.

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Citations

Feb 3, 2021·Journal of Applied Toxicology : JAT·Lin Liu, Lu Kong
May 27, 2021·Environmental Science and Pollution Research International·Shimaa M Abou-ZeidNermeen B El-Borai
Jan 6, 2022·Arhiv za higijenu rada i toksikologiju·Rakhshinda SadiqAsma Shah

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Methods Mentioned

BETA
lavage
MDA
transmission electron microscopy
fluorescence imaging
ELISA
Protein Assay

Software Mentioned

Pro Plus
Cri
ARRIVE
SPSS
Image

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