PMID: 653734Feb 1, 1978Paper

Toxicity of butylated hydroxytoluene in mouse following oral administration

Toxicology
H Witschi, S Lock

Abstract

Male Swiss--Webster mice were given 400 mg/kg of butylated hydroxytoluene ([methyl-14C]toluene) by stomach tube. Radioactivity was measured in plasma, lung, liver and kidney from 0.5 h to 10 days later. Radioactivity associated with butylated hydroxytoluene (BHT) or its metabolites was highest in plasma and all tissues examined between 1 and 12 h after administration. After 24 h, less than 1% of the administered dose remained in the lung, kidney or liver. One day after BHT, DNA synthesis in lung increased and, on days 3, 4 and 5, was 6--8 times as high as in controls. DNA content of the lungs almost doubled. Synthesis and net increase of pulmonary DNA were dose-dependent. If BHT was given orally following injection of one single dose of urethane, adenoma formation in lung was enhanced. It is concluded that BHT, given by stomach tube and in doses higher than 100 mg/kg, produces extensive cell proliferation in mouse lung and acts as a promoting agent in adenoma development.

References

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Sep 1, 1965·Food and Cosmetics Toxicology·J W Daniel, J C Gage

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Citations

Aug 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·M V Evsev'evaF Z Meerson
Jan 1, 1989·Pharmacology & Therapeutics·H WitschiJ A Thompson
Jan 1, 1981·Progress in Lipid Research·D G Cornwell, R V Panganamala
Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O Takahashi
Jun 28, 1985·Toxicology·J P Kehrer, S Kacew
Nov 1, 1986·Toxicology Letters·Y MiyakawaY Hayashi
Jun 1, 1990·Toxicology Letters·J P Kehrer, J DiGiovanni
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R M PattersonJ Stewart
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·K Chan, Y W Kan
Apr 1, 1983·Environmental Health Perspectives·H P Witschi
Apr 1, 1984·Environmental Health Perspectives·H P Witschi, P J Hakkinen
Aug 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K T Kitchin, J L Brown
Jul 24, 2015·American Journal of Respiratory Cell and Molecular Biology·Orquidea GarciaBarbara Driscoll
Sep 30, 1979·Toxicology and Applied Pharmacology·H Witschi, S Lock
Oct 1, 1982·Environmental Research·H Babich
Apr 30, 2003·Japanese Journal of Cancer Research : Gann·Takashi UmemuraYuji Kurokawa
Jan 1, 1984·Drug and Chemical Toxicology·W J Krasavage, J L O'Donoghue
Oct 25, 2002·International Journal of Toxicology·Rebecca S Lanigan, Torill A Yamarik
Nov 1, 1983·Acta Pharmacologica Et Toxicologica·P OlsenO Meyer
Apr 1, 1993·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·R Kahl, H Kappus
Mar 15, 2021·Food Chemistry·Xiaoqing XuMaría-Aránzazu Martínez

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