Toxicity of complex chemical mixtures: acute and long-term effects on different life stages of zebrafish (Brachydanio rerio)

Ecotoxicology and Environmental Safety
U Ensenbach, Roland Nagel

Abstract

Acute and long-term toxicity of 3,4-dichloroaniline and lindane to zebrafish were examined in tap water and water from the Rhine River and the toxicity of the binary mixture 3,4-dichloroaniline/lindane in tap water was investigated. The acute toxicity of 3,4-dichloroaniline and lindane was not influenced by the complex matrix of river water compared with tap water. The binary mixture of 3,4-dichloroaniline and lindane demonstrated an additive effect in the acute test. The survival rate of early life stages in river water was reduced by lindane (80 micrograms/liter), whereas the effects of 3,4-dichloroaniline on survival and growth were visible but not significant. The binary mixture of 2 micrograms/liter, 3,4-dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish.

Citations

Apr 20, 2004·Assay and Drug Development Technologies·Chuenlei ParngPatricia McGrath
Oct 25, 2002·Environmental Pollution·Erwin W M RoexCornelis A M van Gestel
Feb 16, 2007·Environment International·J MartinsV Vasconcelos
Nov 1, 2003·Current Protocols in Toxicology·Chaojie ZhangTrisha Fremgen
May 26, 2017·Environmental Science and Pollution Research International·João AmorimLuis Oliva Teles
Jul 18, 2020·The Science of the Total Environment·Run ZhangLingling Wu

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