Oct 25, 2017

Toxicity of Copper Oxide (CuO) Nanoparticles on Human Blood Lymphocytes

Biological Trace Element Research
Evelyn AssadianJalal Pourahmad


CuO nanoparticles (CuO-NPs) serve several important functions in human life, particularly in the fields of medicine, engineering, and technology. These nanoparticles have been utilized as catalysts, semiconductors, sensors, gaseous and solid ceramic pigments, and magnet rotatable devices. Further use for CuO-NPs has been employed in the pharmaceutical industry especially in the production of anti-microbial fabric treatments or prevention of infections caused by Escherichia coli and methicillin-resistant Staphylococcus aureus. Two key potential routes of exposure to CuO-NPs exist through inhalation and skin exposure. Toxicity of these nanoparticles has been reported in various studies; however, no study as of yet has investigated the complete cellular mechanisms involved in CuO-NPs toxicity on human cells. The aim of this study was to determine the cytotoxicity of CuO-NPs on human blood lymphocytes. Blood lymphocytes were obtained from healthy male subjects through the use of Ficoll polysaccharide subsequently by gradient centrifugation. The following parameters were assayed in blood lymphocytes after a 6-h incubation with different concentrations of CuO-NPs: cell viability, reactive oxygen species (ROS) formation, lipid peroxid...Continue Reading

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Mentioned in this Paper

Copper dioxide (CuO2)
Centrifugation, Density Gradient
Methicillin resistant Staphylococcus aureus (organism)
Cell Injury
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Lymphoid Cells
Mrsa - Methicillin Resistant Staphylococcus Aureus Infection

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