Toxicity of different types of quantum dots to mammalian cells in vitro: An update review

Journal of Hazardous Materials
Na Liu, Meng Tang

Abstract

Currently, there are a great quantity type of quantum dots (QDs) that has been developed by researchers. Depending on the core material, they can be roughly divided into cadmium, silver, indium, carbon and silicon QDs. And studies on the toxicity of QDs are also increasing rapidly, but in vivo tests in model animals fail to reach a consistent conclusion. Therefore, we review the literatures dealing with the cytotoxicity of QDs in mammalian cells in vitro. After a short summary of the application characteristics of five types of QDs, the fate of QDs in cells will be discussed, ranging from the uptake, transportation, sublocation and excretion. A substantial part of the review will be focused on in vitro toxicity, in which the type of QDs is combined with their adverse effect and toxic mechanism. Because of their different luminescent properties, different subcellular fate, and different degree of cytotoxicity, we provide an overview on the balance of optical stability and biocompatibility of QDs and give a short outlook on future direction of cytotoxicology of QDs.

Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mostafa MabroukHanan H Beherei
Apr 20, 2021·Colloids and Surfaces. B, Biointerfaces·Legha AnsariMohammad Amjadi
May 12, 2021·Journal of Applied Toxicology : JAT·Ying LiangMeng Tang
Jun 25, 2021·Nature Communications·Z L ShawSumeet Walia
Dec 4, 2021·Frontiers in Physiology·Barbara FraserRobert J Aitken
Dec 9, 2021·Analytical Chemistry·Hassan NasrollahpourChin Hua Chia
Dec 23, 2021·Journal of Applied Toxicology : JAT·Yongshuai Yao, Meng Tang

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