Toxicity of endogenous and environmental estrogens: what is the role of elemental interactions?

Environmental Health Perspectives
G M StancelD S Loose-Mitchell

Abstract

Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate their physiological actions in target tissues largely via interactions with a nuclear receptor system. The resultant estrogen-receptor complex in turn affects transcription via its interactions with nucleotide sequences known as estrogen response elements (EREs) present in the regulatory regions of hormone responsive genes. A "consensus" ERE sequence GGTCAnnnTGACC was originally identified in the vitellogenin genes of birds and amphibians, but it is now clear that most naturally occurring EREs differ from this sequence in one or more bases. We and others have obtained both in vivo and in vitro data suggesting a differential interaction of receptor complexes containing different ligands with the multiple EREs present in mammalian systems. This raises the possibility that the toxicity of environmental estrogens may arise in part from a differential pattern of ERE activation by environmental compounds relative to endoge...Continue Reading

References

Feb 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C ChiappettaG M Stancel
Feb 1, 1992·Molecular Endocrinology·X S Wu-PengB T Pentecost
Jul 1, 1991·Molecular and Cellular Endocrinology·F E Murdoch, J Gorski
May 1, 1990·Mutation Research·J G Liehr
May 1, 1990·Endocrine Reviews·M A Carson-JuricaB W O'Malley
Apr 1, 1990·Molecular Endocrinology·E P SlaterM Beato
Jul 1, 1990·Molecular Endocrinology·B T PentecostS A Kumar
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M BerryP Chambon
Sep 26, 1972·Biochemical and Biophysical Research Communications·J N AndersonE J Peck
Apr 15, 1971·The New England Journal of Medicine·A L HerbstD C Poskanzer
Sep 1, 1983·Journal of Steroid Biochemistry·P GalandL Flandroy
Jan 1, 1994·Critical Reviews in Eukaryotic Gene Expression·S M HyderD S Loose-Mitchell

❮ Previous
Next ❯

Citations

Sep 25, 1997·Environmental Health Perspectives·S N KalesD C Christiani
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S K DasD B Lubahn
Aug 29, 1998·Environmental Health Perspectives·R BolgerW Checovich
Mar 17, 2001·Environmental Health Perspectives·P L Whitten, H B Patisaul
Dec 19, 2006·Chemical Research in Toxicology·Ching Y WangWilliam J Welsh
Mar 21, 2007·Archives of Pharmacal Research·Seung Min OhKyu Hyuck Chung
May 10, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Thomas K AndreassenBodil Korsgaard
Jun 3, 2009·Environmental Toxicology·Stefan Hallgren, K Håkan Olsén
Aug 28, 2004·Journal of Molecular Graphics & Modelling·Peter Wolohan, David E Reichert
Apr 28, 2006·The Journal of Toxicological Sciences·Hiroaki AoyamaShoji Teramoto
Nov 27, 1996·Environmental Science & Technology·M P M P
Nov 27, 1996·Environmental Science & Technology·M Patlak
Jul 27, 2001·The Journal of the Royal Society for the Promotion of Health·K Jaga, H Duvvi
Aug 30, 2007·Journal of Applied Toxicology : JAT·Gareth S EvansIan Kimber
Apr 1, 2006·Molecular Endocrinology·Sanhita RaySanjoy K Das
Jun 8, 2004·Endocrine Reviews·S K DeyHaibin Wang
Mar 26, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·L Bielory, A Deener
Jun 1, 1996·European Journal of Pediatrics·M E de KokE F Wouters
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·F C LightstoneT C Bruice
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Ines ArmandoJuan M Saavedra
Feb 1, 2007·Annals of Saudi Medicine·F Maleky, S Sarafpur
Dec 29, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Armando Vega-LópezAlejandra García-Gasca
Jun 1, 1997·Regulatory Toxicology and Pharmacology : RTP·H A Barton, M E Andersen
Mar 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·S MattickD J Shapiro
Jun 6, 2006·Applied and Environmental Microbiology·Ines I R BaptistaAndrew G Livingston
May 10, 2002·Environmental Science & Technology·Rupasri MandalDavid R S Lean
Jan 31, 2004·Environmental Science & Technology·Ken SextonMaria T Morandi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.