Toxicity of five protein synthesis inhibiting antibiotics and their mixture to limnic bacterial communities

Aquatic Toxicology
Sara Brosche, Thomas Backhaus

Abstract

Antibiotics are common contaminants of aquatic environments, the protein synthesis inhibitors being one frequently detected class. Even though antibiotics target bacteria, little is known about the sensitivity of naturally occurring freshwater bacteria to these compounds. Limnic bacterial communities were therefore systematically exposed to five common protein synthesis inhibiting antibiotics, each representing a particular subgroup: streptomycin, chloramphenicol, fusidic acid, rifampicin and chlortetracycline. Full concentration-response curves and No Observed Effect Concentrations (NOECs) were determined for all antibiotics, using the (3H)leucine incorporation method. All test compounds were toxic to planktonic communities of limnic bacteria, with EC50s ranging from 0.138 micromol/L for chlortetracycline to 79.1 micromol/L for streptomycin. The order of toxicity was chlortetracycline>rifampicin>fusidic acid>chloramphenicol>streptomycin, based on the individual EC50 values. A comparison to reported chemical monitoring data shows that environmental concentrations of chlortetracycline are in a range that clearly inhibits the protein biosynthesis activity of planktonic bacterial communities. All compounds show exceptionally flat ...Continue Reading

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Jul 26, 2014·Journal of Hazardous Materials·M I VasquezD Fatta-Kassinos
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas Backhaus
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Nov 22, 2019·European Journal of Pharmacology·Ewa FelisEwa Korzeniewska
Mar 19, 2021·Ecotoxicology and Environmental Safety·Naima HamidDe-Sheng Pei

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