Toxicity of functionalized fullerene and fullerene synthesis chemicals

Chemosphere
Paul A IndegliaJean-Claude J Bonzongo

Abstract

Fullerene is one of the most studied carbon-based nanoparticles due to its unique structure and potential for diverse applications. This study focuses on toxicological effects of two fullerene nanomaterials, contributing to ecological as well as human risk assessment strategies. The biological responses from two basic fullerene materials, aqueous-nanoC60 and alkaline-synthesized fullerenol, were examined using four model organisms. Bioassays were conducted on bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) to determine population impacts and to assess mechanisms of cellular effects for both Gram-negative and Gram-positive species. LC50 of aqu-nC60 stirred for 28 days for P. aeruginosa was estimated to be 1336 mg/L; however, toxicity of the same aqu-nC60 preparation for S. aureus was insignificant. Freshwater green algae Raphidocelus subcapitata and invertebrate Ceriodaphnia dubia were exposed to 28-day stirred aqu-nC60 with no significant toxicological impact. Aqu-nC60 stirred for 14 days bore no toxicity within two orders of magnitude greater than the highest concentration administered. LC50 for organisms exposed to alkaline-synthesized fullerenol prepared in the laboratory was 2409 mg/L for P. aeruginosa with no d...Continue Reading

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Citations

Apr 17, 2019·Archives of Toxicology·Svitlana PrylutskaMarcus Frohme
Nov 9, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nechat Sumi, Kumari Chidambaran Chitra
Jun 5, 2020·Ecotoxicology and Environmental Safety·Minh Kim NguyenYoung-Chul Lee

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