Toxicity of high-dose ifosfamide in children

Cancer Chemotherapy and Pharmacology
S M DaviesA W Craft

Abstract

Ifosfamide has been shown to be an active agent in the treatment of several childhood cancers. However, the optimal dose and method of administration remains to be established. The dose/response relationship of ifosfamide suggests that a maximum tolerable, fractionated dose be given, and to reduce hospitalisation this dose should be given in the shortest possible time. A total of 20 patients aged 1-23 years received 124 courses (mean, 6 courses/patient; range, 1-16); 9 subjects had either relapsed or resistant disease, and all of these had previously received cyclophosphamide. A dose of 3 g/m2 ifosfamide was given for 2 (five patients) or 3 (15 patients) successive days. In all, 9 patients received the drug twice daily as a bolus and 11 were given a continuous infusion. All patients received 3 g/m2 mesna per day with ifosfamide and for 12 h there after, and hydration was maintained with 3 l/m2 fluid daily. Myelosuppression occurred in all patients but was mild and reversible, with no toxic deaths. On four occasions in three patients treatment had to be delayed due to myelosuppression. Seven episodes of fever and neutropaenia were successfully treated with antibiotics. The mean glomerular filtration rate in 13 patients at the st...Continue Reading

Citations

Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R ShoreG Koren
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·W GassmannW Mueller-Ruchholtz
Dec 1, 1992·Toxicology Letters·T OkamuraS M Cohen
Jul 1, 1990·Archives of Disease in Childhood·R SkinnerA W Craft
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·W P BradeC E Araujo
Jun 10, 1989·BMJ : British Medical Journal·R SkinnerA W Craft
Jul 1, 1996·Medical and Pediatric Oncology·B J MorlandM C Stevens
Feb 1, 1992·The Annals of Pharmacotherapy·L J Miller, V E Eaton
Apr 14, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Luz María Torres EspíndolaArnoldo Aquino-Gálvez
Jan 1, 1994·Medical and Pediatric Oncology·M J Torres ValdiviesoJ Vara
Jan 1, 1994·Medical and Pediatric Oncology·R RossiH Jürgens
Jan 1, 1994·Medical and Pediatric Oncology·C S BruggersR Delong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.