PMID: 6165428Apr 25, 1981Paper

Toxicity of interferon

British Medical Journal
G M ScottD A Tyrrell

Abstract

The effects of partially purified human leucocyte interferon (PIF) and of a preparation purified by passage twice through a monoclonal antibody affinity chromatography column (NK21F) were compared with those of a control solution in healhty volunteers. After intramuscular injections both interferon preparations caused rises in pulse rate and body temperature, changes in circulating white cell counts, and various unpleasant symptoms, the most common of which were headache, malaise, and fever. Slightly lower doses of NK21F were given, and this was reflected in lower peak serum concentrations. Mean symptom scores, however, were not lower after NK21F than after PIF. Local inflammatory reactions eight hours after intradermal inoculations of these interferons were similar. Purification of interferon using a monoclonal antibody does not reduce the facets of its activity considered in this study. They are therefore inherent in the leucocyte interferon type selected by the antibody.

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Citations

Jan 1, 1982·Cancer Chemotherapy and Pharmacology·A Z RohatinerT A Lister
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·H Kirchner
Mar 1, 1983·European Journal of Pediatrics·S Levin
Sep 1, 1981·Anesthesia Progress·T E Flanagan
Jan 1, 1985·Journal of Neuro-oncology·U BogdahnH Przuntek
May 1, 1992·Journal of the Neurological Sciences·M IkedaH Tsukagoshi
Apr 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B J SlotmanJ J Calame
Mar 29, 2001·Obstetrics and Gynecology·J L Gonzalez-SanchezA F Andrade-Manzano
Oct 27, 1983·The New England Journal of Medicine·C P MauryA M Teppo
Apr 13, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A Majde
Jan 1, 1984·Journal of Interferon Research·H Laude, C La Bonnardiere
Jan 1, 1984·Journal of Interferon Research·S S AlkanH K Hochkeppel
Dec 1, 1990·Archives of Disease in Childhood·D Isaacs
Jun 19, 1982·British Medical Journal·G M ScottD A Tyrrell
Mar 19, 1983·British Medical Journal·J RuutiainenK Cantell
May 28, 1983·British Medical Journal·T Richards
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
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May 1, 1986·Scandinavian Journal of Haematology·E A AbdiP M Venner
Mar 1, 1994·Toxicologic Pathology·T G Terrell, J D Green

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