Toxicity of methyl tertiary-butyl ether on human blood lymphocytes

Environmental Science and Pollution Research International
Ahmad SalimiJalal Pourahmad

Abstract

Methyl tertiary-butyl ether (MTBE) is a synthetic solvent widely used as oxygenate in unleaded gasoline. Few studies have addressed the cellular toxicity of MTBE on some cell lines, and so far, no comprehensive study has been conducted to investigate the probable immunotoxicity of this compound. In this study, the toxicity of MTBE on human blood lymphocytes was evaluated. Blood lymphocytes were isolated from healthy male volunteers' blood, using Ficoll polysaccharide followed by gradient centrifugation. Cell viability, reactive oxygen species (ROS) formation, lipid peroxidation, glutathione levels, and damage to mitochondria and lysosome were determined in blood lymphocytes after 6-h incubation with different concentrations of MTBE (0.1, 0.5, 1, and 2 mM). Our results showed that MTBE, in particular, decreased cell viability, which was associated with significant increase at intracellular ROS level and toxic alterations in mitochondria and lysosomes in human blood lymphocytes. Moreover, it was shown that MTBE strongly provoked lipid peroxidation and also depleted glutathione level at higher concentrations. Interestingly, MTBE exhibited its cytotoxic effects at low concentrations that may resemble to its concentrations in human ...Continue Reading

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Citations

Jul 23, 2019·Journal of Biochemical and Molecular Toxicology·Shabnam RahimiJalal Pourahmad
Jan 28, 2020·Environmental Science and Pollution Research International·Fatemeh SamieiJalal Pourahmad
Dec 21, 2017·Environmental Science and Pollution Research International·Fatemeh GhanbaryAhmad Salimi
Nov 15, 2017·Environmental Toxicology·Junxiang MaPiye Niu
Aug 22, 2018·Environmental Science and Pollution Research International·Musiliu A LiadiMohammed Makkawi
Jul 27, 2017·Toxicological Research·Ahmad SalimiJalal Pourahmad
May 17, 2017·Journal of Biochemical and Molecular Toxicology·Ahmad SalimiJalal Pourahmad
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reham Z HamzaNahla S El-Shenawy
Jun 10, 2021·Expert Opinion on Drug Metabolism & Toxicology·Ahmad SalimiHassan Ghobadi

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