Toxicity of mixtures of perfluorooctane sulphonic acid with chlorinated chemicals and lipid regulators

Chemosphere
Karina BoltesEloy García-Calvo

Abstract

The toxicological interaction of perfluorooctane sulphonic acid (PFOS) with the chlorinated pollutants triclosan and 2,4,6-trichlorophenol and the lipid regulators gemfibrozil and bezafibrate was evaluated using the combination index-isobologram equation. The endpoint for bioassays was the growth rate inhibition of the green alga Pseudokirchneriella subcapitata. The results showed that most of the binary combinations assayed exhibited antagonism at all effect levels. The addition of a third component induced a less antagonistic or even synergistic behaviour. This was particularly marked for the ternary mixture of triclosan and 2,4,6-trichlorophenol with PFOS, for which synergism was very strong at all effect levels, with a combination index as low as 0.034 ± 0.002 at EC(50) for the mixture. The results obtained indicate that the evaluation of mixture toxicity from single component data using the concentration addition approach could severely underestimate combined toxicity.

References

Oct 5, 2002·Chemosphere·Kurunthachalam KannanJohn P Giesy
Jan 31, 2004·Environmental Science & Technology·Jonathan W MartinScott A Mabury
Apr 15, 2004·The Science of the Total Environment·Marianna Czaplicka
Mar 8, 2005·Archives of Environmental Contamination and Toxicology·M L HansonK R Solomon
Feb 27, 2007·Environment International·Marina IsidoriAlfredo Parrella
Sep 4, 2007·The Science of the Total Environment·A Koutsaftis, I Aoyama
Apr 1, 2009·Environmental Science and Pollution Research International·Roberto RosalAlice Petre
Aug 10, 2010·Environmental Pollution·Axel MöllerPim de Voogt
Sep 11, 2010·Environmental Pollution·Kyle E MurrayAdria A Bodour

❮ Previous
Next ❯

Citations

Apr 22, 2015·The Science of the Total Environment·Conrad MarxVolker Kuehn
Jun 14, 2014·Environmental Toxicology and Chemistry·Lutz Ahrens, Mirco Bundschuh
Feb 26, 2016·Journal of Toxicology and Environmental Health. Part a·Gabriela V SvartzCristina S Pérez Coll
Jan 18, 2015·Environmental Science and Pollution Research International·Guiling YangQiang Wang
Sep 4, 2014·Environmental Science and Pollution Research International·Francesca CoperchiniLuca Chiovato
Jul 23, 2016·Chemosphere·Ainara Domínguez-GarayAbraham Esteve-Núñez
Jun 24, 2017·Microbial Biotechnology·Ainara Domínguez-GarayAbraham Esteve-Núñez
Nov 24, 2017·Archives of Environmental Contamination and Toxicology·Meghan MarshallViviane Yargeau
May 30, 2019·International Journal of Molecular Sciences·Krystian Miazek, Beata Brozek-Pluska
Dec 25, 2019·The Science of the Total Environment·Jin Wuk LeePilje Kim
Jun 6, 2021·The Science of the Total Environment·Vanessa F FonsecaPatrick Reis-Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.