Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
F LicastroF Stirpe

Abstract

A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds of Momordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells.

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Citations

Nov 29, 2017·International Journal of Molecular Sciences·Shuo JiaJianhua Xie
Aug 25, 2010·Cancer Science·Pornsiri PitchakarnTomoyuki Shirai
Jul 26, 2019·BMC Complementary and Alternative Medicine·Muhammad Farooq KhanMohammad A M Wadaan
Jun 14, 2018·Current Protein & Peptide Science·Senjam Sunil SinghRobert Thangjam
Jun 1, 1989·Japanese Journal of Cancer Research : Gann·R Sakai
Jan 1, 1983·International Journal of Immunopharmacology·F SpreaficoF Stirpe
Dec 21, 1993·Biochimica Et Biophysica Acta·L BarbieriF Stirpe
Jun 9, 2004·Journal of Ethnopharmacology·J K Grover, S P Yadav

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