Toxicity of pesticides toward human immune cells U-937 and HL-60

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Anna BarbaszAgnieszka Czyżowska

Abstract

The industrialization of the agricultural sector has significantly increased the use of chemicals such as pesticides. Therefore, exposure to them is unavoidable, which makes it necessary to assess their safety for humans at actual exposure doses. This paper aims to determine toxicity of three types of pesticides toward human immune cells (HL-60 and U-937): glyphosate (GLY), deltamethrin (DEL), and chlorothalonil (CHL). Cell viability, membrane integrity, inflammation induction, and antioxidant activity were evaluated to determine differences in cellular response to the tested plant protection agents. In experimental models, all tested substances caused increased mortality of cells after only 24 h. Cell membrane damage was recorded under DEL and CHL influences. The largest disintegration of the cell membrane was due to the action of 100 μg/mL DEL for U-937 and CHL at 1 μg/mL for HL-60. GLY at a concentration of 3,600 μg/mL caused significant peroxidation of U-937 cells' lipids. CHL-induced inflammation in both types of cells tested. DEL and GLY also induced antioxidant activity in cells. These results lead to the conclusion that the tested pesticides act cytotoxically to the cells of the human immune system in doses to which bot...Continue Reading

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Citations

Apr 12, 2021·Environmental Science and Pollution Research International·Muhammad Shahjahan UsmaniRahil Irfan Ahmed
Aug 3, 2021·Environmental Research·Corina LesseurJia Chen
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro

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