Toxicity of polyhydroxylated fullerene to mitochondria

Journal of Hazardous Materials
Li-Yun YangYi Liu

Abstract

Mitochondrial dysfunction is considered as a crucial mechanism of nanomaterial toxicity. Herein, we investigated the effects of polyhydroxylated fullerene (C60(OH)44, fullerenol), a model carbon-based nanomaterial with high water solubility, on isolated mitochondria. Our study demonstrated that fullerenol enhanced the permeabilization of mitochondrial inner membrane to H(+) and K(+) and induced mitochondrial permeability transition (MPT). The fullerenol-induced swelling was dose-dependent and could be effectively inhibited by MPT inhibitors such as cyclosporin A (CsA), adenosine diphosphate (ADP), ruthenium red (RR) and ethylenediaminetetraacetic acid (EDTA). After treating the mitochondria with fullerenol, the mitochondrial membrane potential (MMP) was found collapsed in a concentration-independent manner. The fluorescence anisotropy of hematoporphyrin (HP) changed significantly with the addition of fullerenol, while that of 1,6-diphenyl-hexatriene (DPH) changed slightly. Moreover, a decrease of respiration state 3 and increase of respiration state 4 were observed when mitochondria were energized with complex II substrate succinate. The results of transmission electron microscopy (TEM) provided direct evidence that fullerenol ...Continue Reading

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Citations

Jan 26, 2016·Journal of Hazardous Materials·Ping DongFeng-Lei Jiang
Nov 30, 2016·Journal of Bioenergetics and Biomembranes·Guo-Min ZhangZhi-Hai Lei
May 18, 2018·Journal of Bioenergetics and Biomembranes·Long MaYi Liu
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Nov 13, 2019·The Science of the Total Environment·Daming WuTing Zhang
Jan 11, 2021·Journal of Hazardous Materials·Iruthayapandi Selestin RajaDong-Wook Han
Mar 19, 2021·Environmental Science and Pollution Research International·Paula BimováTomáš Mackuľak
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lianjie YeMeilan Yu
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Apr 9, 2021·Biotechnology and Applied Biochemistry·Varun Pratap SinghIndrani Banerjee
Dec 16, 2017·Environmental Science & Technology·Josep SanchísMarinella Farre

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