Toxicity of pristine and paint-embedded TiO2 nanomaterials

Human & Experimental Toxicology
Anne T SaberHåkan Wallin

Abstract

Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO2NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO2NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 µg of TiO2NMs or 54, 162 and 486 µg of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO2NMs and sanding dusts with different types of TiO2NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO2NMs and paint dusts with TiO2NMs caused similar type of histological lesions in the liver.

References

May 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·K E DriscollR B Schlesinger
Aug 20, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Ken DonaldsonVicki Stone
Feb 2, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel L CostaKevin L Dreher
Jan 14, 2009·Particle and Fibre Toxicology·Nicklas Raun JacobsenHåkan Wallin
May 21, 2010·Journal of Exposure Science & Environmental Epidemiology·Ismo Kalevi KoponenThomas Schneider
Jun 16, 2010·Particle and Fibre Toxicology·Karin S HougaardUlla Vogel
Feb 4, 2012·Particle and Fibre Toxicology·Anne Thoustrup SaberHåkan Wallin
Apr 17, 2013·Particle and Fibre Toxicology·Hongbo ShiJinshun Zhao
Jun 14, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stijn SmuldersPeter H M Hoet

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Methods Mentioned

BETA
lavage
transmission electron microscopy
scanning electron microscopy
dynamic light scattering
electrophoresis
bronchoalveolar lavage

Software Mentioned

SAS
Graph Pad
Graph Pad Prism
IMSTAR

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