PMID: 7336967Jul 1, 1981Paper

Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse

Acta Pharmacologica Et Toxicologica
S H SterriF Fonnum

Abstract

Injection of sublethal doses of soman in guinea-pig and mouse subcutaneously every 3.5, 8, 12 or 24 hours led to cumulative LD50 doses which were markedly higher than the acute one. When animals were exposed every 24 hrs to half LD50 doses of soman, a majority of guinea-pigs but relatively few mice, survived a total exposure of 5-6 times the acute LD50 dose. Guinea-pig brain and diaphragm acetylcholinesterase activities declined steadily during the repeated soman exposure. Plasma cholinesterase activity was less than 10% 1 hr after soman injection, but was restored to 40-50% of control within 24 hrs. Liver aliesterase activity was not significantly inhibited by soman, whereas plasma aliesterase activity was 70% inhibited after 1 hr and restored to control level within 24 hrs. TOCP treatment of guinea-pig led to 3-fold increase in acute soman toxicity, and reduced their tolerance from more than 6 lD50 to 2.5 LD50 dose of soman. It is included that the recovery of plasma aliesterase and cholinesterase play an important part in the observed tolerance towards repeated soman treatment.

References

Jul 1, 1979·Acta Pharmacologica Et Toxicologica·S H SterriS Lyngaas
Mar 1, 1970·Biochemical Pharmacology·R L Polak, E M Cohen
Mar 1, 1966·The Biochemical Journal·D B CoultG Read
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·S H SterriF Fonnum

❮ Previous
Next ❯

Citations

Jan 1, 1987·Archives of Toxicology·R C Gupta, W D Dettbarn
Aug 1, 1985·Acta Pharmacologica Et Toxicologica·S H SterriF Fonnum
Oct 1, 1985·Archives of Toxicology·T KadarS Shapira
Jul 1, 1993·Journal of Toxicology and Environmental Health·D A JettA T Eldefrawi
Jan 1, 1981·Acta Pharmacologica Et Toxicologica·S H Sterri
May 15, 2004·Prehospital and Disaster Medicine·Pål Aas
Oct 1, 1985·Acta Pharmacologica Et Toxicologica·M D DulaneyI K Ho
Nov 1, 1990·Archives of Environmental Contamination and Toxicology·R C Gupta, W L Kadel
Jan 1, 1989·Journal of Toxicology and Environmental Health·R C Gupta, W L Kadel
Jun 15, 1983·Biochemical Pharmacology·S H SterriF Fonnum
Jun 1, 1986·Biochemical Pharmacology·P AasF Fonnum
Feb 15, 1990·Biochemical Pharmacology·M Jokanović
Mar 15, 1987·Toxicology and Applied Pharmacology·R C GuptaW D Dettbarn
Aug 1, 1987·Toxicology and Applied Pharmacology·R C Gupta, W D Dettbarn
Feb 1, 1991·Toxicology and Applied Pharmacology·B VeronesiC Pope

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.