Toxicity of sulphur mustard in adult rat lung organ culture

Toxicology
T W SawyerM T Weiss

Abstract

The toxicity of the chemical warfare agent sulphur mustard, (bis-(2-chloroethyl)sulphide, HD), was examined in adult rat lung organ cultures. Assessment of HD-induced damage by the MTT cytotoxicity assay indicated that the median lethal concentration (LC50) of HD in these cultures was reproducible, and in the microM range. Damage to the lung slices was expressed only after a latent period of 48 h and did not increase significantly with longer expression times. Histopathological examination of HD-treated lung cultures showed that the structural changes in the lung tissue paralleled the toxicity measured biochemically, and were also similar to the damage found in animals and man exposed to HD in vivo. This in vitro model offers a useful tool with which to study the toxicity and mechanism of action of sulphur mustard.

References

Nov 1, 1979·The Journal of Pediatrics·R R Minor
Aug 1, 1991·Archives of Dermatology·W J Smith, M A Dunn
Apr 1, 1991·Trends in Pharmacological Sciences·U Wormser
Dec 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B PapirmeisterJ B Johnson
Mar 15, 1989·Toxicology and Applied Pharmacology·M A MolA W Kluivers
Sep 15, 1987·Toxicology and Applied Pharmacology·M E Placke, G L Fisher
Aug 1, 1983·Annals of the Rheumatic Diseases·V J Hajiroussou, M Webley
May 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M A Mol, A M de Vries-van de Ruit

❮ Previous
Next ❯

Citations

Jun 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C MonteilJ P Fillastre
Jun 30, 2012·Critical Reviews in Toxicology·Feng Ru Tang, Weng Keong Loke
Oct 4, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jean-Paul MorinChristelle Monteil
Oct 2, 2001·Toxicology and Applied Pharmacology·R BhattacharyaR Vijayaraghavan
Aug 19, 2020·Annals of the New York Academy of Sciences·Julia HerbertJeffrey D Laskin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.