Toxicity of tributyltin (TBT) to the freshwater planarian Schmidtea mediterranea

Chemosphere
Pearl U OfoegbuJoão L T Pestana

Abstract

The freshwater planarian Schmidtea mediterranea, one of the best characterized animal models for regeneration research and developmental biology, is being recognised as a useful species for ecotoxicological studies. Sensitive endpoints related to planarians' behaviour and regeneration can be easily evaluated after exposure to environmental stressors. In this work the sensitivity of S. mediterranea to a gradient of environmentally relevant concentrations of TBT was studied using multiple endpoints like survival, locomotion, head regeneration and DNA damage. In addition, a feeding assay based on planarian's predatory behaviour was performed. Results indicated that TBT is toxic to planarians with LC50's of 1.87 μg L(-1) Sn and 1.31 μg L(-1) Sn at 48 h and 96 h of exposure respectively. Sub-lethal exposures to TBT significantly reduced locomotion and feeding, delayed head regeneration and caused DNA damage in planarians. The behavioural endpoints (feeding and locomotion) and head regeneration were the most sensitive parameters followed by DNA damage. Similar to other aquatic model organisms, S. mediterranea showed high sensitivity towards TBT exposure. Based on our results, and though further research is required concerning their s...Continue Reading

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Citations

Feb 20, 2018·Environmental Science and Pollution Research International·Althiéris S SaraivaAmadeu M V M Soares
Feb 25, 2019·Environmental Science and Pollution Research International·Pearl U OfoegbuJoāo L T Pestana
Jun 20, 2020·Environmental Science and Pollution Research International·Aline Silvestre Pereira DornelasJoão L T Pestana
Jan 1, 2020·Ecotoxicology and Environmental Safety·Amanda da Silveira GuerreiroJuliana Zomer Sandrini
Sep 17, 2021·Environmental Science and Pollution Research International·Laila Cristina Rezende SilvaRenato Almeida Sarmento

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