Toxicity response of highly colloidal, bioactive, monodisperse SiO2 @ Pr(OH)3 hollow microspheres

Colloids and Surfaces. B, Biointerfaces
Anees A AnsariAbdulaziz A Al-Khedhairy

Abstract

In a facile synthesis, highly colloidal, bioactive Pr(OH)3-encapsulated silica microspheres (PSMSs) with an average diameter of 500-700 nm were successfully prepared via a sol-gel process followed by heat treatment. The phase formation, morphology, surface and optical properties of the as-synthesized PSMSs were characterized by various techniques including X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscope (SEM), transmission electron microscope (TEM), N2-adsorption-desorption, energy dispersive X-ray (EDX) analysis, Fourier transform infrared (FTIR) and UV/vis spectroscopy. The PSMSs were semi-amorphous or ultra-small in size, highly dispersible in water, mesoporous, irregular in size and spherical in shape. The SEM images show a well-ordered broad nanoporous structure which is preserved after coating with Pr(OH)3 molecules, demonstrating interaction between the optically active Pr3+ ion and silanol (Si-OH) groups via hydrogen bonding. Optical spectra show well-resolved weak intensity 4f-4f absorption transitions in the visible region of the Pr3+ ion, indicating successful grafting of the Pr(OH)3 layer. Toxicity was measured by MTT and NRU assays to determine potential toxicity. Cell viabil...Continue Reading

Citations

May 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giulia NeriEnza Fazio
Aug 28, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anees A AnsariMuhammad Ali Shar

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