Toxicity studies on Secretio Bufonis: a traditional supplement in Asia

Journal of Acupuncture and Meridian Studies
Won-Seung YooHwa-Seung Yoo

Abstract

This study was performed to investigate the toxicity of Secretio Bufonis (SB) on male mice and assess its no-observed-adverse-effect-level (NOAEL). After feeding an aqueous solution of SB extracts to mice for either 1 or 8 weeks, their blood and urine were assayed and their liver and kidney morphology examined. The numerical data was analyzed by the Mann-Whitney U-test and analysis of variance test. Mice administered SB in 50 mg/kg/day for 1 week had higher heart weights and higher aspartate transaminase activities; those administered SB in 0.01 and 0.05 mg/kg/day for 8 weeks had lower creatinine concentrations; and those administered SB in 0.5 mg/kg/day for 8 weeks had higher brain weights and higher blood urea nitrogen. The extracts of SB had cardiac toxicity in the short term and hepatotoxicity in the long term. The NOAEL of the extract was under 5 mg/kg/day for 1 week and under 0.25 mg/kg/day for 8 weeks.

References

Dec 1, 1967·Journal of Pharmaceutical Sciences·K K Chen, A Kovaríková
Nov 9, 2004·Toxicon : Official Journal of the International Society on Toxinology·John W DalyTanya Chan-Ard

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Citations

Mar 6, 2012·Phytotherapy Research : PTR·Shuli ManChangxiao Liu

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