Toxicity study of Vernonia cinerea

Pharmaceutical Biology
Lachimanan Yoga LathaSreenivasan Sasidharan

Abstract

The methanol extract of Vernonia cinerea Less (Asteraceae), which exhibited antimicrobial activity, was tested for toxicity. In an acute toxicity study using mice, the median lethal dose (LD(50)) of the extract was greater than 2000 mg/kg, and we found no pathological changes in macroscopic examination by necropsy of mice treated with extract. As well as the oral acute toxicity study, the brine shrimp lethality test was also done. Brine shrimp test LC(50) values were 3.87 mg/mL (6 h) and 2.72 mg/mL (24 h), exhibiting no significant toxicity result. In conclusion, the methanol extract of V. cinerea did not produce toxic effects in mice and brine shrimp.

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Citations

Apr 11, 2012·International Journal of Molecular Sciences·Vanessa Dos Santos TemponiOrlando Vieira Vieira de Sousa
Feb 12, 2013·Journal of Ethnopharmacology·Ngeh J Toyang, Rob Verpoorte
Nov 27, 2014·Natural Product Research·Nittya K Dogra, Suresh Kumar
Oct 4, 2016·Journal of Ethnopharmacology·Oratai Neamsuvan, Pattaraporn Bunmee
Jun 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hasandeep SinghBalbir Singh

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