Toxicogenetics of lopinavir/ritonavir in HIV-infected European patients

Personalized Medicine
Elena López AspirozThe Tormes Team

Abstract

We present a genetic association study in 106 European HIV-infected individuals aimed at identifying and confirming polymorphisms that have a significant influence on toxicity derived from treatment with lopinavir/ritonavir (LPV/r). Genotyping was performed by matrix-assisted laser desorption/ionization-time of flight and KASPar® (KBiosciences, Hoddesdon, UK); LPV/r plasma concentrations were quantified using HPLC with an UV detection system and the pharmacokinetic parameters were estimated using Bayesian algorithms. Genetic association analysis was performed with PASW Statistics 18 (SPSS Inc., IL, USA) and R for Windows (Microsoft, WA, USA). Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene. Replication analysis should confirm the novel results obtained in this study prior to its application in the clinical practice to achieve a safer LPV/r-based combined antiretroviral therapy.

References

May 1, 1980·Clinical Pharmacokinetics·K M Piafsky
Jun 22, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Carr
Jun 28, 2002·The New England Journal of Medicine·Sharon WalmsleyUNKNOWN M98-863 Study Team
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Bernard MasquelierUNKNOWN Groupe d' Epidémiologie Clinique du SIDA en Aquitaine
Feb 21, 2003·The New England Journal of Medicine·Samuel A BozzetteThomas A Louis
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Félix GutiérrezAlberto Martin-Hidalgo
Nov 1, 2003·AIDS Patient Care and STDs·Daniel González de RequenaVincent Soriano
Jun 19, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nanette I SteinleAlan R Shuldiner
Apr 6, 2005·The Journal of Infectious Diseases·Philip E TarrUNKNOWN Swiss HIV Cohort Study
Apr 4, 2006·Clinical Pharmacology and Therapeutics·Anna Westlind-JohnssonOliver von Richter
Feb 3, 2007·Bioinformatics·Juan R GonzálezVíctor Moreno
Mar 27, 2007·Gastroenterology·Tobias LiebregtsGerald Holtmann
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
Aug 19, 2007·Pharmacogenetics and Genomics·Mireia ArnedoUNKNOWN Swiss HIV Cohort Study
Dec 17, 2008·Enfermedades infecciosas y microbiología clínica·M Mar Gutiérrez MaciáPere Domingo Pedrol
Apr 18, 2009·Current Opinion in HIV and AIDS·Andrew Owen, Saye H Khoo
Feb 9, 2010·Pharmacogenetics and Genomics·Rubin LubomirovUNKNOWN Swiss HIV Cohort Study
Jan 1, 2007·CSH Protocols·Edwin Cuppen
Sep 14, 2011·Therapeutic Drug Monitoring·Elena López AspirozMaría José García Sánchez
Feb 4, 2012·Current Drug Metabolism·Jennifer L PilgrimOlaf H Drummer
Jul 19, 2013·Pharmacogenomics·Almudena Sánchez MartínAngel Carracedo Álvarez
Sep 1, 2014·Personalized Medicine·Elena López AspirozMaría José García Sánchez

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Citations

Aug 31, 2020·NPJ Genomic Medicine·Takuto TakahashiPamala A Jacobson
May 2, 2020·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Michael A CharyMichele M Burns
Feb 13, 2021·NPJ Genomic Medicine·Takuto TakahashiPamala A Jacobson

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Methods Mentioned

BETA
PCR
Genotyping

Software Mentioned

SNPassoc
SPSS
R
PASW Statistics
ENSEMBL

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