Toxicogenomics data: the road to acceptance

Environmental Health Perspectives
Kris Freeman

Abstract

Regulatory agencies believe microarray data could be extremely useful in testing prospective chemical products and investigating safety problems after chemicals have been marketed. However, it has not yet been clearly established how this information will be used by agencies in the approval of pharmaceuticals and other chemicals--or even whether companies will be required to submit microarray data. Although some private companies are already voluntarily submitting microarray data along with their drug and pesticide applications, others are hesitant to do so. Most of the stakeholders involved agree that standardization of microarray experiment procedures and of genomic signatures are key to the broad acceptance and use of these data.

Citations

Jul 9, 2005·Environmental Health Perspectives·Brenda K WeisSamuel H Wilson
Mar 25, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Steven A Enkemann
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Jan 17, 2020·Integrated Environmental Assessment and Management·Matthieu MondouNiladri Basu

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Methods Mentioned

BETA
chip
chips
biopsy

Software Mentioned

MIAME
ArrayExpress
DrugMatrix
Expression Analysis

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